半岛bd体育手机客户端 说明
一般描述
Truncated human sequence (amino acids 178-241) corresponding to the EGF domain and purified as a GST-fusion protein, cleaved with thrombin.
生化/生理作用
Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation. The phosphorylated receptors recruit cellular signaling proteins, initiating signaling pathways.
外形
Solution in phosphate buffered saline containing 30% glycerol.
分析说明
Stimulates tyrosine phosphorylation of the ErbB-3/HER-3 receptor.
The biological activity is measured by its ability to activate the c-ErbB3/HER-3 receptor in treated MCF-7 cells.
基本信息
MDL编号 | MFCD01867052 |
NACRES | NA.32 |
半岛bd体育手机客户端 性质
质量水平 | 200 |
生物来源 | human |
重组 | expressed inE. coli |
测定 | ≥80% (SDS-PAGE) |
形式 | buffered aqueous glycerol solution |
分子量 | 185 kDa |
包装 | pkg of 100 μg |
储存条件 | avoid repeated freeze/thaw cycles |
UniProt登记号 | Q02297 |
运输 | dry ice |
储存温度 | ?20℃ |
Gene Information | human ... NRG1(3084) |
安全信息
储存分类代码 | 12 - Non Combustible Liquids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich