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Heregulin-β, EGF Domain human

品牌
Sigma-Aldrich
货号
H0786
规格纯度
≥80% (SDS-PAGE), recombinant, expressed inE. coli, buffered aqueous glycerol solution
价格
9015.14 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Heregulin-β, EGF Domain human
HRG-β
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Truncated human sequence (amino acids 178-241) corresponding to the EGF domain and purified as a GST-fusion protein, cleaved with thrombin.

生化/生理作用

Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation. The phosphorylated receptors recruit cellular signaling proteins, initiating signaling pathways.

外形

Solution in phosphate buffered saline containing 30% glycerol.

分析说明

Stimulates tyrosine phosphorylation of the ErbB-3/HER-3 receptor.
The biological activity is measured by its ability to activate the c-ErbB3/HER-3 receptor in treated MCF-7 cells.

基本信息

MDL编号 MFCD01867052
NACRES NA.32

半岛bd体育手机客户端 性质

质量水平 200
生物来源 human
重组 expressed inE. coli
测定 ≥80% (SDS-PAGE)
形式 buffered aqueous glycerol solution
分子量 185 kDa
包装 pkg of 100 μg
储存条件 avoid repeated freeze/thaw cycles
UniProt登记号 Q02297
运输 dry ice
储存温度 ?20℃
Gene Information human ... NRG1(3084)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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