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Hirudin

品牌
Sigma-Aldrich
CAS
8001-27-2
货号
H0393
规格纯度
recombinant, expressed in unspecified host, ≥7,000 ATU/mg protein (ATU = antithrombin units)
价格
4082.29 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
8001-27-2
Hirudin
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

Antithrombotic efficacy by parenteral route is substantially prolonged by incorporation into cationic liposomes, which act as a sort of sustained-release device.

物理属性

The anticoagulant hirudin is a ~7 kDa acidic protein containing 65 amino acid residues. It occurs naturally in leeches (Hirudo medicinalis). It is the most potent natural inhibitor of both soluble and clot-bound thrombin. Hirudin binds thrombin with high affinity and covers more than 20% of the surface area of thrombin, occluding both the active site and exosite I (fibrinogen and PAR recognition site). This coverage blocks thrombus growth and platelet activation. Hirudin is not metabolized in the bloodstream of humans and is eliminated unchanged via kidney filtration. Native hirudin contains a sulfated tyrosyl residue (Tyr63), three disulfide bridges, and a high proportion of dicarboxylic acids. Hirudin is not glycosylated, and lacks tryptophan, arginine, and methionine residues. At least 20 isoforms have been identified and sequenced.
This recombinant hirudin product corresponds to the HV-1 variant sequence, with the exception that the Tyr63residue is not sulfated.

单位定义

One unit (ATU) will neutralize one NIH unit of thrombin at 37 ℃, based on direct comparison to an NIH thrombin reference standard.

重悬

Hirudin is soluble in water. The literature cites the use of "Dilution Fluid II" (35.7 mM acetic acid, 35.7 mM sodium diethyl barbiturate, 0.85% NaCl, 1% bovine serum albumin, and 0.5% PEG, pH 7.4) to dissolve hirudin (500 ATU/mL) and thrombin. Hirudin is reported to be soluble in pyridine, but practically insoluble in alcohol, ether, acetone, or benzene.

分析说明

Protein determined by Lowry.

基本信息

EC 号 232-279-1
MDL编号 MFCD00145679
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 200
重组 expressed in unspecified host
形式 powder
specific activity ≥7,000 ATU/mg protein (ATU = antithrombin units)
分子量 ~7 kDa
溶解性 pyridine: soluble
water: soluble
运输 dry ice
储存温度 ?20℃

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 dust mask type N95 (US), Eyeshields, Gloves

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