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Anti-EGFR Antibody, clone 528 (Azide-free)

品牌
Sigma-Aldrich
货号
MABF119
规格纯度
clone 528, from mouse
价格
5520.38 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Anti-EGFR Antibody, clone 528 (Azide-free)
Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The epidermal growth factor receptor (EGFR; Proto-oncogene c-ErbB-1) is a ubiquitously receptor tyrosine kinase that is activated by a variety of ligands including EGF, EPGN, TGFA, and EREG. Ligand-bound EGFR undergoes dimerization and autophosphorylation exposing cytoplasmic domains which allow interaction with adaptor proteins and induction of several signaling pathways including PI3-AKT; PLCγ-PKC; Notch1; and Ras-Raf. EGFR therefore contributes to a diverse range of cellular processes inlcuding cell proliferation. Several studies have reported that EGFR signaling plays an important role in the development of various tumors. EGFR is regulated by PTPRJ and PTPRK phosphatases, and by the endocytic machinery including EPS15 that mediates internalization and degradation of the receptor.

特异性

This antibody recognizes the extracellular domain of EGFR.

免疫原

Partially purified human EGFR from A431 cells

应用

Neutralizing Assay Analysis: A representative lot was used by an independent laboratory in A431 cells. (Kawamoto, T., et al. (1984). Journal of Biological Chemistry. 259(12):7761-7766.)
Anti-EGFR Antibody, clone 528 (Azide-free) detects level of EGFR & has been published & validated for use in Immunoprecipitation, Neutralizing.

质量

Evaluated by Immunoprecipitation in A431 cell lysate.

Immunoprecipitation Analysis: 10 ?g of this antibody immunoprecipitated EGFR from A431 cell lysate.

目标描述

~170 kDa observed. Uniprot gives a calculated molecular weight of 135 but can be observed at ~170 kDa due to phosphorylation. (Konishi, A., et al. (2003). The Journal of Biological Chemistry. 278(37):35049–35056.)

联系

Replaces: 04-338

外形

Protein G Purified
Format: Purified

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
抗体形式 purified antibody
antibody product type primary antibodies
克隆 528, monoclonal
species reactivity human
technique(s) immunoprecipitation (IP): suitable
neutralization: suitable
同位素/亚型 IgG2aκ
NCBI登记号 NP_005219
UniProt登记号 P00533
运输 dry ice

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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