半岛bd体育手机客户端 说明
一般描述
A non-steroidal anti-inflammatory, cell permeable, antipyretic agent. Non-selective COX inhibitor (IC50= 740 nM for COX-1; IC50= 970 nM for COX-2). Inhibits phospholipase A2(IC50= 145 ?M). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation and suppresses production of Aβ-peptide and secreted form of APP by inhibition of APP mRNA levels in NG108-15 cells.
A cell-permeable, non-steroidal anti-inflammatory, anti-pyretic agent. Non-selective cyclooxygenase (COX) inhibitor (IC50= 740 nM for COX-1; IC50= 970 nM for COX-2). Inhibits phospholipase A2(IC50= 145 ?M). Reported to reduce Aβ42levels independently of COX activity.
包装
10 g in Alu drum
生化/生理作用
Cell permeable: yes
Product does not compete with ATP.
Reversible: no
警告
Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)
其他说明
Kodoyama, K., et al. 2001.Biochem. Biophys. Res. Commun.281,483.
Weggen, S., et al. 2001.Nature414,212.
Kalgutkar, A.S., et al. 2000.Proc. Natl. Acad. Sci. USA97,925.
Klabunde, T., et al. 2000.Nat. Struct. Biol.7,312.
Futaki, N., et al. 1994.Prostaglandins47,55.
Futaki, N., et al. 1994.Prostaglandins47,55.
Stevenson, K.M., and Lumbers, E.R. 1992.J. Dev. Physiol.17,257.
Oliw, E. 1980.Prostaglandins19,271.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C19H16ClNO4 |
| 分子量 | 357.79 |
| MDL编号 | MFCD00057095 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (by assay) |
| 形式 | powder |
| 效能 | 740 nM IC50 |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze |
| 颜色 | white to off-white |
| 溶解性 | ethanol: 20 mg/mL |
| 运输 | ambient |
| 储存温度 | 10-30℃ |
| InChI | 1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23) |
| InChI key | CGIGDMFJXJATDK-UHFFFAOYSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Danger |
| 危险声明 | H300 |
| 预防措施声明 | P264 - P270 - P301 + P310 - P405 - P501 |
| 危险分类 | Acute Tox. 1 Oral |
| 储存分类代码 | 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
