Mevastatin-CAS 73573-88-3-Calbiochem

半岛bd体育手机客户端 说明

一般描述

An antibiotic that acts as a potent inhibitor of HMG-CoA reductase, thus suppressing Ras farnesylation. Inhibitor of myoblast fusion. Also may induce bone morphogenic protein-2 (BMP-2). Causes cell cycle arrest in late G₁phase.
This is an inactive form which may require activation for use with isolated cells depending upon the application. To activate, treat with NaOH in ethanol and then neutralize to pH 7.2.
An antibiotic that acts as a potent inhibitor of HMG-CoA reductase, thus suppresses Ras farnesylation. Inhibitor of myoblast fusion. Causes cell cycle arrest in late G₁phase. May induce bone morphogenic protein-2 (BMP-2). This product requires activation for use in cell culture and cell-free assay systems. To activate, treat with ethanol solution with 1 N NaOH and then neutralize with 1 N HCl to pH 7.2 (see Keyomarsi, K . et al. 1991).

包装

50 mg in Plastic ampoule

生化/生理作用

Primary Target
HMG-CoA reductase
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

其他说明

Sugiyama, M., et al. 2000.Biochem. Biophys. Res. Commun.271,688.
Hug, T., et al. 1995.Pflugers Archiv. Eur. J. Physiol.429,682.
Belo, R.S., et al. 1993.Mol.Cell. Biochem.126,159.
McLeish, K.R., et al. 1993.Biochem. Biophys. Res. Commun.197,763.
Keyomarsi, K., et al. 1991.Cancer Res.51,3602.
Jackson, J.H., et al. 1990.Proc. Natl. Acad. Sci. USA87,3042.
Kita, T., et al. 1980.J. Clin. Invest.66,1094.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C23H34O5
分子量	390.51
MDL编号	MFCD05662341

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze
颜色	white
溶解性	ethanol: soluble
运输	ambient
储存温度	2-8℃
InChI	1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1
InChI key	AJLFOPYRIVGYMJ-INTXDZFKSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable