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位置: 首页> 品牌> Sigma-Aldrich> Pefloxacin 甲磺酸酯 二水合物

Pefloxacin mesylate dihydrate

Pefloxacin 甲磺酸酯 二水合物

品牌
Sigma-Aldrich
CAS
149676-40-4
货号
P0106
包装型号
规格纯度
价格
420.97 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
149676-40-4
Pefloxacin mesylate dihydrate
Pefloxacinium methanesulfonate dihydrate
Pefloxacine monomethanesulfonate dihydrate
3-Quinolinecarboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-, monomethanesulfonate, dihydrate
Pefloxacin 甲磺酸酯 二水合物
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Chemical structure: fluoroquinolone

应用

Pefloxacin is a synthetic broad-spectrum fluoroquinolone antibiotic that is effective against most gram-negative and gram-positive bacteria. It is used to treat gonococcal urethritis and for gram-negative-bacterial infections in the gastrointestinal system and the genitourinary tract. Pefloxacin mesylate dihydrate has been used to induce achilles tendon toxicity in rodents. It′s cytotoxicity and uptake have been studied in primary cultures of rat hepatocytes.

包装

10, 50 g in poly bottle

生化/生理作用

Pefloxacin inhibits the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited . Pefloxacin is an analog of norfloxacin.

其他说明

Keep container tightly closed in a dry and well-ventilated place.

基本信息

线性分子式 C17H20FN3O3? CH4O3S ? 2H2O
分子量 465.49
EC 号 274-613-9
MDL编号 MFCD01685696
PubChem化学物质编号 329820015

半岛bd体育手机客户端 性质

质量水平 100
溶解性 H2O: 50 mg/mL
作用机制 DNA synthesis | interferes
enzyme | inhibits
抗生素抗菌谱 Gram-negative bacteria
Gram-positive bacteria
储存温度 2-8℃
SMILES string O.O.CS(O)(=O)=O.CCN1C=C(C(O)=O)C(=O)c2cc(F)c(cc12)N3CCN(C)CC3
InChI 1S/C17H20FN3O3.CH4O3S.2H2O/c1-3-20-10-12(17(23)24)16(22)11-8-13(18)15(9-14(11)20)21-6-4-19(2)5-7-21;1-5(2,3)4;;/h8-10H,3-7H2,1-2H3,(H,23,24);1H3,(H,2,3,4);2*1H2
InChI key LEULAXMUNMRLPW-UHFFFAOYSA-N

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H319
预防措施声明 P305 + P351 + P338
危险分类 Eye Irrit. 2
储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 dust mask type N95 (US), Eyeshields, Gloves

Sigma-Aldrich

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