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位置: 首页> 品牌> Sigma-Aldrich> Anti-Growth Factor Independence-1 antibody, Mouse monoclonal

Anti-Growth Factor Independence-1 antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
G6670
规格纯度
clone 2.5D.17, purified from hybridoma cell culture
价格
6923.34 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-Growth Factor Independence-1 antibody, Mouse monoclonal
Anti-ZNF163
Anti-GFI1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Monoclonal Anti-Growth Factor Independence-1 (GFI1) (mouse IgG1 isotype) is derived from the hybridoma 2.5D.17 produced by the fusion of mouse myeloma cells (SP2 cells) and splenocytes from BALB/c mice immunized with rat GFI1. Growth Factor Independence 1 (GFI1) is a zinc-finger transcriptional repressor, that is located on human chromosome 1p22. Gfi1 is highly expressed in thymus while Gfi1B is the predominant factor expressed in spleen, and both are expressed in bone marrow. It has a repression domain named SNAG at the N-terminal.? The protein also has a zinc finger DNA binding domain that is homologous to the domain in Gfi1B. Both bind to same consensus DNA sequence

特异性

The antibody epitope resides within the GFI1 SNAG transcriptional-repression domain (amino acids 7-26).

免疫原

rat growth factor independence-1 (GFI1).

应用

Monoclonal Anti-Growth Factor Independence-1 (GFI1) antibody may be used in:

  • immunoblotting
  • immunohistochemistry
  • EMSA (electrophoretic mobility shift analysis)

生化/生理作用

Growth factor independence-1 (Gfi1) plays a key role in hematopoiesis along with Gfi1B proteins. Cytokines that regulate innate immunity induce Gfi1 expression. Deficiency of this protein causes thymic and peripherial T lymphopenia and severe abnormalities in pre-T-cell development in mice. Mutations in this gene cause defects in T lymphocyte function and development in humans. Gfi1 autoregulates its expression in T lymphocytes.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

分析说明

The antibody may also be used in EMSA (electrophoretic mobility shift analysis).

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD02263329
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 200
生物来源 mouse
偶联物 unconjugated
抗体形式 purified from hybridoma cell culture
antibody product type primary antibodies
克隆 2.5D.17, monoclonal
形式 buffered aqueous solution
分子量 antigen ~55 kDa
species reactivity mouse, rat, human
浓度 ~2 mg/mL
technique(s) immunohistochemistry: suitable
microarray: suitable
western blot: 1-2 μg/mL using total cell extract of A549 cells
同位素/亚型 IgG1
UniProt登记号 Q99684
运输 dry ice
储存温度 ?20℃
Gene Information human ... GFI1(2672)
mouse ... Gfi1(14581)
rat ... Gfi1(24388)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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