半岛bd体育手机客户端 说明
免疫原
synthetic peptide corresponding to the N-terminal extracellualr domain of human metabotropic glutamate receptor 6, conjugated to KLH. The immunizing peptide has 100% homology with the rat and mouse gene.
应用
Anti-Glutamate Receptor 6, Metabotropic antibody is suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 12μg/mL using human ganglion layer, retina.
生化/生理作用
Glutamate, the excitatory neurotransmitter, is involved in fast excitatory synaptic transmission. It acts on ligand-gated receptor channels, termed NMDA, AMPA and kainate receptors. The metabotropic form consist of eight subtypes (mGluR1-8) divided into three groups (I-III). Group I binds to phospholipase C and intracellular calcium mobilization, whereas both groups II and III inhibit adenyl cyclase. The metabotropic receptors have some therapeutic potentials. group I receptors have been implicated in post-ischemic neuronal injury, and antagonists of group I appear to have a neuroprotective effect.
外形
Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.
基本信息
MDL编号 | MFCD03097014 |
NACRES | NA.41 |
半岛bd体育手机客户端 性质
生物来源 | rabbit |
质量水平 | 200 |
偶联物 | unconjugated |
抗体形式 | affinity isolated antibody |
antibody product type | primary antibodies |
克隆 | polyclonal |
形式 | buffered aqueous solution |
species reactivity | human |
availability | not available in Japan |
technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 12 μg/mL using human ganglion layer, retina |
UniProt登记号 | O15303 |
运输 | dry ice |
储存温度 | ?20℃ |
Gene Information | human ... GRM6(2916) mouse ... Grm6(108072) rat ... Grm6(24419) |
安全信息
储存分类代码 | 12 - Non Combustible Liquids |
WGK | nwg |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich