GROα human

半岛bd体育手机客户端 说明

一般描述

GROα, also called CXCL1 (chemokine (C-X-C motif) ligand 1), is a member of the small soluble chemokine protein family. It belongs to the C-X-C subfamily, which is comprised of 17 members. It contains a conserved glutamic acid-leucine-arginine (ELR) domain. This protein is expressed on stromal cells such as, endothelial cells, fibroblasts and blood-circulating cells.

生化/生理作用

GROα, also called CXCL1 (chemokine (C-X-C motif) ligand 1), plays an essential role in neutrophil recruitment, and the initiation of angiogenesis. This gene is up-regulated in multiple cancer types such as, gastric cancer, renal cell carcinoma, prostate cancer and melanoma. The expression of this protein is also elevated in HER2 positive metastatic breast cancer. Its expression is increased in fibroblasts, which might be involved in breast tumor progression, and its stromal expression in breast cancer is linked to poor prognosis. This gene is also up-regulated in the aggressive phenotype of bladder cancer. Polymorphism rs4074 A in this gene is also associated with susceptibility to alcoholic cirrhosis.

外形

Lyophilized from a 0.2 μm filtered solution in 25% acetonitrile and 0.1% trifluoroacetic acid containing 50 μg bovine serum albumin per 1 μg of cytokine.

分析说明

The biological activity is measured by its ability to induce chemotaxis of mouse BaF/3 cells transfected with hCXCR2.

基本信息

EC 号	200-835-2
MDL编号	MFCD00677959
NACRES	NA.32

半岛bd体育手机客户端 性质

质量水平	100
生物来源	human
重组	expressed inE. coli
测定	≥97% (SDS-PAGE)
形式	lyophilized powder
效能	1.0-4.0 ng/mL
分子量	~7.9 kDa
包装	pkg of 10 μg
储存条件	avoid repeated freeze/thaw cycles
technique(s)	cell culture | mammalian: suitable
杂质	endotoxin, tested
UniProt登记号	P09341
储存温度	?20℃
Gene Information	human ... CXCL1(2919)

安全信息

象形图
警示用语：	Danger
危险声明	H225 - H302 + H312 + H332 - H319
预防措施声明	P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
危险分类	Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
储存分类代码	3 - Flammable liquids
WGK	WGK 2
闪点(F)	35.6 °F - (Acetonitrile)
闪点(C)	2.0 ℃ - (Acetonitrile)
个人防护装备	Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter