Gly-Pro-Glu

半岛bd体育手机客户端 说明

一般描述

IGF1 (insulin-like growth factor 1) protein is cleaved into des-N-(1-3)-IGF-1 and anN-terminal Gly-Pro-Glu (GPE tripeptide). It is thought to be an outcome of specific neural processing.

包装

10, 50 mg in glass bottle

生化/生理作用

Gly-Pro-Glu is a neuroprotective compound and the N-terminal tripeptide of IGF-1. Gly-Pro-Glu is neuroprotective after central administration in animal models of neurodegenerative processes, such as Huntington′s, Parkinson′s, Alzheimer′s diseases, and varies acute brain injury animal models. The neuroprotective activity is not related to its affinity to glutamate receptor. Findings indicate that GPE mimics insulin-like growth factor I effects on the somatostatin system through a mechanism independent of β-amyloid clearance that involves modulation of calcium and glycogen synthase kinase 3β signaling.
Gly-Pro-Glu (GPE) is a neuroactive peptide and prevents the binding of glutamate toN-methyl-D-aspartate (NMDA) receptor. It positively regulates the potassium-mediated release of acetylcholine from rat cortical slices. Thus, it is involved in the control of brain function.In vitrostudies show that this peptide confers neuroprotection to CA1-2 hippocampal neurons against excitotoxic insult.

其他说明

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. G3923.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

基本信息

经验(实验)分子式	C12H19N3O6
分子量	301.30
MDL编号	MFCD00144405
PubChem化学物质编号	329799919
NACRES	NA.32

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white
储存温度	?20℃
SMILES string	NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(O)=O
InChI	1S/C12H19N3O6/c13-6-9(16)15-5-1-2-8(15)11(19)14-7(12(20)21)3-4-10(17)18/h7-8H,1-6,13H2,(H,14,19)(H,17,18)(H,20,21)/t7-,8-/m0/s1
InChI key	JJGBXTYGTKWGAT-YUMQZZPRSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable