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GYKI 52466 hydrochloride

品牌
Sigma-Aldrich
CAS
192065-56-8
货号
G119
规格纯度
solid
价格
1700.13 *本价格含增值税费
促销
服务
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数量
- +
半岛bd体育手机客户端 名称:
192065-56-8
GYKI 52466 hydrochloride
1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

GYKI 52466 hydrochloride has been used as an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor selective antagonist in cell viability assays to evaluate the specificity of kainate (KA) effect on cerebellar granule cells (CGCs). It has also been used as an AMPA blocker to study the function of glutamate in neuroadapted sindbis virus (NSV) -induced motor neuron death.

包装

10, 25, 100 mg in glass bottle

生化/生理作用

GYKI 52466 serves as an antagonist of several processes, mediated by glutamate.
Selective allosteric AMPA receptor antagonist; anticonvulsant; skeletal muscle relaxant.

特点和优势

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

法律信息

Sold under exclusive license from the Institute for Drug Research Ltd., Budapest, Hungary.

基本信息

经验(实验)分子式 C17H15N3O2· HCl
分子量 329.78
MDL编号 MFCD00153803
PubChem化学物质编号 24277984
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 solid
颜色 yellow
溶解性 DMSO: 0.39 mg/mL
ethanol: 0.4 mg/mL
0.1 M HCl: 0.68 mg/mL
methanol: 1 mg/mL
H2O: >10 mg/mL
SMILES string Cl[H].CC1=NN=C(c2ccc(N)cc2)c3cc4OCOc4cc3C1
InChI 1S/C17H15N3O2.ClH/c1-10-6-12-7-15-16(22-9-21-15)8-14(12)17(20-19-10)11-2-4-13(18)5-3-11;/h2-5,7-8H,6,9,18H2,1H3;1H
InChI key RUBSCPARMVJNKX-UHFFFAOYSA-N
Gene Information human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 dust mask type N95 (US), Eyeshields, Gloves

Sigma-Aldrich

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