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位置: 首页> 品牌> Sigma-Aldrich> Monoclonal Anti-Fas Ligand antibody produced in rat

Monoclonal Anti-Fas Ligand antibody produced in rat

品牌
Sigma-Aldrich
货号
F2928
规格纯度
clone 101624, purified immunoglobulin, lyophilized powder
价格
4731.57 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Monoclonal Anti-Fas Ligand antibody produced in rat
Anti-FasL
Anti-CD95L
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Fas Ligand is a 40kDa type II membrane protein, which also known as FasL and CD95L, belongs to the tumor necrosis factor (TNF) family. In the new TNF superfamily nomenclature, FasL is referred as TNFSF6. It consists of TNFα, α and β chains of lymphotoxin (LT), CD40 ligand, and CD30 ligand. It also has four potential N-glycosylation sites which appear to be variably used.

免疫原

purified recombinant mouse Fas Ligand, amino acids 132-279, expressed in NSO cells.

应用

The monoclonal Anti-Fas Ligand antibody is suitable for western blot analysis of rat thymus homogenates to detect the recombinant rFasL molecule. The antibody is also suitable for immunoblotting at a concentration of 1-2μg/ml and ELISA at a concentration of 0.5-1.0μg/ml.

生化/生理作用

FasL is predominantly expressed on activated T cells and NK cells, whereas Fas is expressed on various cell types. The gene expression is induced by the activation of mature T cells with phorbol myristic acetate (PMA) and ionomycin, concanavalin A (Con A) or anti-CD3. After cleaving of FasL, it can generate the soluble Fas ligand, a non-covalently linked homotrimer. Membrane-bound FasL and TNFα are primary activators of their receptors. Soluble FasL may inhibit the killing effect of membrane FasL. It plays an important role in modulating immune response by inducing cell apoptosis to maintain homeostasis, self-tolerance of lymphocytes, and immune privilege. It has chemoattractant characteristics for neutrophils which indicate proinflammatory function.

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD00283210
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 200
生物来源 rat
偶联物 unconjugated
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 101624, monoclonal
形式 lyophilized powder
species reactivity mouse
technique(s) neutralization: suitable
western blot: 1-2 μg/mL
同位素/亚型 IgG1
储存温度 ?20℃
Gene Information mouse ... Fasl(14103)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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