Fas/Fc Chimera from mouse

半岛bd体育手机客户端 说明

一般描述

Fas is a key component of apoptosis, and is a cell surface receptor. This gene is localized to human chromosome 10q24.1, and is composed of nine exons and eight introns.

应用

Fas/Fc Chimera from mouse has been used as a blocking agent during FACS (flow cytometry).

生化/生理作用

Fas and its ligand play an essential role in apoptosis, by activating the cell death signaling pathway. Mutations in this gene are associated with evasion of apoptosis by cells, leading to tumorigenesis, and prevention of clearance of these cells by the immune system. A polymorphism in this gene results in the production of soluble Fas (sFas), which is implicated in the chronic autoimmune disorder called primary Sj?gren′s syndrome (pSS).

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 50 μg bovine serum albumin per 1 μg of cytokine.

分析说明

Biological activity was measured by its ability to inhibit Fas-ligand induced apoptosis of Jurkat cells.

基本信息

MDL编号	MFCD01867037
NACRES	NA.32

半岛bd体育手机客户端 性质

质量水平	200
重组	expressed in baculovirus infectedSf21 cells
测定	>97% (SDS-PAGE)
形式	lyophilized powder
效能	0.03-0.1 μg per mL ED50(in the presence of 20 ng/mL recombinant human Fas ligand for cytotoxicty assay of Jurkat cells)
分子量	55 kDa (glycosylated form)
technique(s)	cell culture | mammalian: suitable
杂质	endotoxin, tested
UniProt登记号	P25446
储存温度	?20℃
Gene Information	mouse ... Fas(14102)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable