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Anti-FOXA1 antibody produced in rabbit

Anti-FOXA1 兔抗

品牌
Sigma-Aldrich
货号
F1555
规格纯度
IgG fraction of antiserum, buffered aqueous solution
价格
7037.8 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-FOXA1 antibody produced in rabbit
Anti-HNF3A
Anti-MGC33105
Anti-Hepatocyte nuclear factor 3α
Anti-forkhead box A1
Anti-TCF3A
Anti-FOXA1 兔抗
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

FOXA1 gene is mapped to human chromosome 14q21.1. FOXA1 belongs to the FOXA family. Forkhead proteins comprise “winged helix” DNA binding or forkhead domain.
Forkhead box protein A1 (FOXA1) is a protein encoded by the FOXA1 gene in humans and is a member of the FOX family of transcription factors.

特异性

Anti-FOXA1 specifically recognizes human FOXA1.

免疫原

synthetic peptide corresponding to amino acids 441-459 of human FOXA1, conjugated to KLH via a N-terminal cysteine residue.

应用

Anti-FOXA1 antibody produced in rabbit has been used in immunoblotting.
Anti-FOXA1 antibody produced in rabbit is suitable for indirect immunofluorescence at a dilution of 1:100-1:200 using MCF7 cells fixed with paraformaldehyde-Triton. It is also suitable for western blotting at a dilution of 1:250-1:500 using extracts of the MCF7 cell line.

生化/生理作用

Forkhead box protein A1 (FOXA1) exhibits the greatest extent of mitotic chromosome binding. FOXA1 is involved in embryonic development and cell differentiation. It promotes cell proliferation by androgen receptor (AR) and activates Notch pathway. FOXA1 acts as a negative regulator in the initial stages of lung cancer metastasis. It may modulate the epithelial-to-mesenchymal transition through its transcriptional regulatory network. FOXA1 has been implicated in certain tumor types including breast, prostate, lung, thyroid and esophageal squamous cell carcinomas. It might act as a potential regulator of progression of human glioma.
FOXA group of proteins are referred to as “pioneer factors” as they interact with compacted chromatin and make them accessible for transcription factors. FOXA1 is a crucial partner in events that lead to breast cancer progression in connection with estrogen receptor (ER).

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

储存及稳定性

For continuous use, store at 2-8 ℃ for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD09265359
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 IgG fraction of antiserum
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen 50 kDa
species reactivity human
technique(s) indirect immunofluorescence: 1:100-1:200 using MCF7 cells fixed with paraformaldehyde-Triton
western blot: 1:250-1:500 using extracts of the MCF7 cell line
UniProt登记号 P55317
运输 dry ice
储存温度 ?20℃
Gene Information human ... FOXA1(3169)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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