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位置: 首页> 品牌> Sigma-Aldrich> Anti-CD8a (Mouse), clone 53-6.7, biotin conjugate Antibody

Anti-CD8a (Mouse), clone 53-6.7, biotin conjugate Antibody

品牌
Sigma-Aldrich
货号
MABF153E
规格纯度
clone 53-6.7, from rat, purified by affinity chromatography
价格
1415.25 *本价格含增值税费
促销
服务
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  • 增值税票
数量
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半岛bd体育手机客户端 名称:
Anti-CD8a (Mouse), clone 53-6.7, biotin conjugate Antibody
T-cell surface glycoprotein CD8 alpha chain, T-cell surface glycoprotein Lyt-2, CD8a, CD8a
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The 53-6.7 antibody reacts with the 32-34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.The 53-6.7 antibody is widely used as a phenotypic marker for mouse CD8a expression on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells.

应用

Anti-CD8a (Mouse), clone 53-6.7, biotin conjugate Antibody detects level of CD8a and has been published and validated for use in Flow Cytometry.

质量

This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.125 μg from a representative lot detected CD8a in one million C57Bl/6 splenocytes.

外形

Purified by size-exclusion chromatography

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702

半岛bd体育手机客户端 性质

质量水平 100
生物来源 rat
抗体形式 purified antibody
antibody product type primary antibodies
克隆 53-6.7, monoclonal
纯化方式 affinity chromatography
species reactivity mouse
包装 antibody small pack of 25 μg
technique(s) flow cytometry: suitable
UniProt登记号 P01731

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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