Anti-Endothelial Cell Protein C Receptor antibody, Rat monoclonal

半岛bd体育手机客户端 说明

一般描述

Monoclonal Anti-endothelial cell protein C receptor (EPCR) (rat IgG2a isotype) is derived from the RCR379 hybridoma produced by the fusion of mouse SP2/0 myeloma cells and lymphatic cells isolated from the superficial inguinal lymph nodes from Wister rats immunized with human EPCR-positive RE-1 cells. Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor), is a protein encoded by the PROCR gene in humans and is mapped to the locus 20q11.22. EPCR is a type 1 transmembrane glycoprotein containing two domains in the extracellular region that are homologous to the α1 and α2 domains of CD1/ major histocompatibility complex class 1 (MHC) class 1 molecules. It is expressed exclusively in endothelial cells and small vessels such as capillaries of the alveolar wall in the lung.

特异性

Monoclonal Anti-Endothelial Cell Protein C Receptor (EPCR) recognizes human EPCR (49 kDa).

免疫原

human EPCR-positive RE-1 cells.

应用

Monoclonal Anti-Endothelial Cell Protein C Receptor antibody produced in rat is suitable for flow cytometry at a concentration of 5-20μg/mL using HUVEC cells.
Monoclonal Anti-Endothelial Cell Protein C Receptor antibody produced in rat may be used in immunohistochemistry.

包装

200 μL in glass insert

生化/生理作用

The EPCR protein also performs other functions, like binding to proteinase. The complex then binds to macrophage 1 antigen (MAC-1) on activated neutrophils and inhibits their adhesion to activated endothelium
Endothelial protein C receptor (EPCR) also known as activated protein C receptor (APC receptor) is involved in regulation of the cytoprotective and anticoagulant pathways of protein C. EPCR is a member of the CD1/major histocompatibility complex superfamily and plays an important role in regulating the inflammatory response. It is also identified as an endothelial receptor for specificP. falciparumerythrocyte membrane protein 1 (PfEMP1) subtypes. EPCR is associated with an increased risk of venous thromboembolism (VTE).

外形

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

储存及稳定性

For continuous use, store at 2-8 ℃ for up to one month. For prolonged storage, freeze in working aliquots at ?20 ℃. Repeated freezing and thawing is not recom-mended. Storage in frost-free freezers is also not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号	MFCD04118502
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	200
生物来源	rat
偶联物	unconjugated
抗体形式	purified from hybridoma cell culture
antibody product type	primary antibodies
克隆	RCR-379, monoclonal
形式	buffered aqueous solution
species reactivity	human
technique(s)	flow cytometry: 5-20 μg/mL using HUVEC cells
同位素/亚型	IgG2a
UniProt登记号	Q9UNN8
运输	dry ice
储存温度	?20℃
Gene Information	human ... PROCR(10544)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)