Monoclonal Anti-E2F6 antibody produced in mouse

半岛bd体育手机客户端 说明

一般描述

E2F6 transcription factor belongs to the third class of E2Fs. The E2F transcription factors are a family of genes that play critical roles in regulation of cellular proliferation and differentiation.

免疫原

recombinant human E2F6 protein

应用

Monoclonal Anti-E2F6 antibody produced in mouse is suitable for immunocytochemistry and indirect ELISA. It is also suitable for western blotting at a working concentration of 2-4μg/mL using HeLa nuclear cell extract.

生化/生理作用

The third class of E2Fs lacks both the retinoblastoma protein binding and transcriptional activation domain, and is an active repressor of transcription. The activity of E2F6 is mediated through its recruitment of polycomb transcriptional repressor complexes in a histone methylation independent manner. E2F6 associates with E2F target genes that are activated at G1/S phase. Its repression activity during the S-phase distinguishes G1/S and G2/M transcription during cell cycle. It may be involved in various cancerous processes.

外形

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

半岛bd体育手机客户端 性质

质量水平	200
生物来源	mouse
偶联物	unconjugated
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	TFE61, monoclonal
形式	buffered aqueous solution
分子量	antigen ~35 kDa
species reactivity	human
浓度	~1.0 mg/mL
technique(s)	immunocytochemistry: suitable indirect ELISA: suitable western blot: 2-4 μg/mL using HeLa nuclear cell extract
同位素/亚型	IgG1
UniProt登记号	O75461
运输	dry ice
储存温度	?20℃
Gene Information	human ... E2F6(1876)

安全信息

储存分类代码	12 - Non Combustible Liquids
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)