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位置: 首页> 品牌> Sigma-Aldrich> Nidogen-1 (NID1) human

Nidogen-1 (NID1) human

品牌
Sigma-Aldrich
货号
D8935
规格纯度
recombinant, expressed in HEK 293 cells, suitable for cell culture
价格
4054.44 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Nidogen-1 (NID1) human
NID
NID1
Entactin
NID-1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Nidogen-1 belongs to the nidogens family of glycoproteins. This family consists of nidogen-1 and nidogen-2, both of which are sulfated monomeric glycoproteins. Nidogen-1 is ubiquitously present in the synaptic and extra synaptic basal lamina. It is mapped to human chromosome 1q42.3. Nidogen-1 encodes a 139 kDa, three globular domains namely G1, G2 and G3 and has multiple epidermal growth factor repeats. Recombinant human nidogen-1 is expressed in human HEK 293 cells as a glycoprotein with a calculated molecular mass of 133.5 kDa (amino acids 29-1247). This protein is manufactured in human cells, with no serum. The human cells expression system allows human-like glycosylation and folding, and often supports higher specific activity of the protein. The protein is produced with no artificial tags.

应用

This recombinant human nidogen-1 product can be used as an attachment factor for cells adherence.

生化/生理作用

Nidogen-1 (NID-1) is thought to have an important role in the construction of basement membrane by linking between the networks of laminin and collagen IV. Genetic elimination of the nidogen-1 binding site on the mouse laminin γ1 chain leads to impaired deposition of basement membranes and hampers microvessel maturation. Nidogen 1 and 2 double knockout in mouse fibroblasts led to the loss of all major basal membrane components from the epidermal-collagen interface, and complete abolishment of hemidesmosomes. Supplementation by either recombinant nidogen-1 or -2 improved basal membrane formation. Mutations in NID1and laminin γ1 is implicated in pathogenesis of Dandy-Walker spectrum disorders.

半岛bd体育手机客户端 性质

重组 expressed in HEK 293 cells
测定 95% (SDS-PAGE)
形式 lyophilized powder
technique(s) cell culture | mammalian: suitable
储存温度 ?20℃

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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