Monoclonal Anti-DYNLT3 antibody produced in mouse

半岛bd体育手机客户端 说明

一般描述

Monoclonal Anti-DYNLT3 (mouse IgG2a isotype) is derived from the hybridoma R1 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with rat dynein 3 light chain-myosin basic protein fusion protein. DYNLT3 belongs to the Tctex-light chain family. It is also known as rp3.
DYNLT3 has been located in both the cytoplasm and the nucleus, in cell- and tissue-specific manners. The subunit binds to SATB1 complex and the activity of this complex is independent of the dynein motor.

免疫原

rat dynein 3 light chain myosin basic protein fusion protein.

应用

Monoclonal Anti-DYNLT3 antibody produced in mouse has been used in immunoblotting and immunoprecipitation.

生化/生理作用

Cytoplasmic dynein motor complex is responsible for minus-end, microtubule-based motile processes. It is thus involved in a wide range of eukaryotic cellular processes including trafficking of membranal vesicles, viruses and other intracellular particles. DYNLT3 is a light chain subunit of the complex that binds to Bub3, a spindle checkpoint protein and is depleted from the kinetochore during chromosome alignment. It contributes to dynein cargo binding specificity as dynein binds directly to a component of the spindle checkpoint complex through this light chain. The interaction of the Herpes simplex virus capsid protein VP26 with dynein light chains facilitates the binding of the virus capsid to cytoplasmic dynein during cellular infection.

外形

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES

NA.41

半岛bd体育手机客户端 性质

质量水平	200
生物来源	mouse
偶联物	unconjugated
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	R1, monoclonal
形式	buffered aqueous solution
分子量	antigen ~12.5 kDa
species reactivity	human, rat
浓度	~1.0 mg/mL
technique(s)	immunoprecipitation (IP) : suitable western blot: 2-4 μg/mL using rat brain S1 extract
同位素/亚型	IgG2a
UniProt登记号	P51808
运输	dry ice
储存温度	?20℃
Gene Information	human ... DYNLT3(6990) rat ... Dynlt3(363448)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	nwg
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)