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DPO-1

品牌
Sigma-Aldrich
CAS
43077-30-1
货号
D7443
规格纯度
needles, >97% (NMR)
价格
1700.13 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
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半岛bd体育手机客户端 名称:
43077-30-1
DPO-1
(1S,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl]diphenyl-phosphine oxide
(+)-Neomenthyl diphenylphosphine oxide
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

包装

5, 25 mg in glass bottle

生化/生理作用

DPO-1 is an inhibitor of human Kv1.5 potassium channel; representative blocker of a novel pharmacophore. The Kv1.5 potassium channel, which underlies the ultrarapid delayed rectifier current, IKur, is reported to be enriched in human atrium versus ventricle, and has been proposed as a target for novel atrial antiarrhythmic therapy. The administration of the IKurblocker (2-isopropyl-5-methyl-cyclohexyl) diphenylphosphine oxide (DPO-1) increases myocardial refractoriness in both atrium and ventricle of rat, but produces an atrial-selective increase in refractoriness in primates; appears to be 15-fold more selective for Kv1.5 vs Kv3.1 channels expressed inXenopus oocytes. IC50= 0.16-0.76 μM at 0.1 Hz pulsing frequency; Kd= 0.6 μM.

特点和优势

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式 C22H29OP
分子量 340.44
MDL编号 MFCD09038567
PubChem化学物质编号 329798851
NACRES NA.77

半岛bd体育手机客户端 性质

测定 >97% (NMR)
形式 needles
储存条件 protect from light
颜色 white
溶解性 DMSO: 2 mg/mL, clear (warmed)
储存温度 2-8℃
SMILES string CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1P(=O)(c2ccccc2)c3ccccc3
InChI 1S/C22H29OP/c1-17(2)21-15-14-18(3)16-22(21)24(23,19-10-6-4-7-11-19)20-12-8-5-9-13-20/h4-13,17-18,21-22H,14-16H2,1-3H3/t18-,21+,22+/m1/s1
InChI key BPCNGVCAHAIZEE-COPCDDAFSA-N

Sigma-Aldrich

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