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Anti-Calsequestrin-1 (N-terminal) antibody produced in rabbit

Anti-Calsequestrin-1 (N-terminal) 兔抗

品牌
Sigma-Aldrich
货号
C0743
规格纯度
affinity isolated antibody
价格
4731.57 *本价格含增值税费
促销
服务
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  • 增值税票
数量
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半岛bd体育手机客户端 名称:
Anti-Calsequestrin-1 (N-terminal) antibody produced in rabbit
Anti-Calsequestrin-skeletal muscle isoform
Anti-Aspartactin
Anti-CASQ1
Anti-CALMITINE
Anti-Calsequestrin-1 (N-terminal) 兔抗
Aspartactin
CASQ1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

免疫原

synthetic peptide corresponding to amino acids 28-45 located near the N-terminus of mouse calsequestrin-1, conjugated to KLH. This sequence is identical in rat and highly conserved in human and bovine calsequestrin-1 (two amino acid substitution). This sequence is not found in calsequestrin-2.

应用

Anti-Calsequestrin-1 (N-terminal) antibody produced in rabbit is suitable for western blotting at a concentration of 0.5-1μg/mL using extracts of rat skeletal muscle S1 fraction.

生化/生理作用

Calsequestrin (CS) is a calcium-binding protein in the sarcoplasmic reticulum (SR). It is known as CSQ and PDIB1. The gene belongs to calsequestrin protein family. Calsequestrin-1 is a putative auto-antigen associated with eye muscle inflammation in Graves′ disease. Calsequestrin-2 (55 kDa) is found in the SR′s terminal cisternae luminal space of cardiac, slow skeletal muscle cells and may be in platelets. The major Ca2+ binding protein in cardiac and skeletal muscle is a high-capacity, low-affinity Ca2+ binding glycoprotein, which functions as an internal Ca2+ store in the lumen of the SR. It helps in controlling the smooth-muscle contraction.

目标描述

Calsequestrin (CS also known as CSQ), the major Ca2+binding protein in cardiac and skeletal muscle, is a high-capacity, low-affinity Ca2+binding glycoprotein, which functions as an internal Ca2+store in the lumen of the SR. In mammalians, two forms of the protein are found, calsequestrin-1 (CASQ-1) and calsequestrin-2 (CASQ-2), which encode the fast-twitch skeletal muscle and cardiac calsequestrin, respectively. Calsequestrin-1 is found in the SRs terminal cisternae luminal space of fast skeletal muscle cells. Calsequestrin-1 is a putative autoantigen associated with eye muscle inflammation in Graves′ disease.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD09265356
NACRES NA.44

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen ~60 kDa
species reactivity bovine (predicted), rat, human (predicted), mouse
浓度 ~1.0 mg/mL
technique(s) western blot: 0.5-1 μg/mL using extract of rat skeletal muscle S1 fraction
UniProt登记号 P31415
运输 dry ice
储存温度 ?20℃
Gene Information human ... CASQ1(844)
mouse ... Casq1(12372)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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