半岛bd体育手机客户端 说明
生化/生理作用
CDK6 is a member of the cyclin-dependent family of protein kinases that are important regulators of cell cycle progression. CDK6 activity is regulated by the D-type cyclins and members of the INK4 family of CDK inhibitors. The CDK6 kinase activity is detected in mid-G1 phase of the cell cycle and is responsible for the phosphorylation and regulation of the activity of tumor suppressor protein Rb. Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivityin vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein.
外形
Supplied in 50 mM Sodium Phosphate, pH 7.0, with 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, and 25% glycerol.
法律信息
PRECISIO is a registered trademark of sigma-aldrich Co. LLC
半岛bd体育手机客户端 性质
| 质量水平 | 200 |
| 重组 | expressed in baculovirus infectedSf9 cells |
| 半岛bd体育手机客户端 线 | PRECISIO?Kinase |
| 测定 | ≥70% (SDS-PAGE) |
| 形式 | buffered aqueous glycerol solution |
| specific activity | 7.9-10.7 nmol/min·mg |
| 分子量 | CDK6 subunit ~40 kDa cyclin D1 ~61 kDa |
| UniProt登记号 | P24385 Q00534 |
| 运输 | dry ice |
| 储存温度 | ?70℃ |
| Gene Information | human ... CCND1(595), CDK6(1021) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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