Anti-phospho-α-B Crystallin (54-64) (pSer⁵⁹) antibody produced in rabbit

半岛bd体育手机客户端 说明

一般描述

α-B-crystallin (CRYAB) belongs to small heat-shock protein family with chaperone-like function. Almost entire lens proteins composed of crystallins and within that α-crystallin accounts for 40% of total lens protein. α-Crystallin is composed of two primary gene products, α-A and α-B. α-B crystallin in particular, has been detected in many tissues in the central nervous system, and is considered to be a useful marker in a variety of neurodegenerative diseases.

特异性

This antibody does not detect the unphosphorylated form of the protein.

免疫原

synthetic phosphopeptide: FLRAPS(p)WIDTG

应用

Anti-phospho-α-B Crystallin (54-64) (pSer⁵⁹) antibody is suitable for indirect immunofluorescence in 8μg/mL using human brain from Alexander′s diseased patients. It is also suitable for western blot analysis in concentration of 0.5μg/mL using recombinant bovine phospho-α-B crystallin (Ser⁵⁹).

生化/生理作用

Anti-phospho-α-B Crystallin (54-64) (pSer⁵⁹) antibody is responsible for the optical properties of the lens and have been identified from metabolic enzymes and stress proteins. In many neurological diseases, α B-crystallin have found over-expressed and any alterations in this protein leads cataract and myopathy. In addition to maintaining proper refractive index, it also functions in a chaperone-like manner by preventing the formation of aggregates possibly leading to cataract formation. It is believed that the phosphorylated states of α-crystallin occur in response to cellular stress and may serve a structural control function and play a role in protein maintenance.

外形

Lyophilized from phosphate buffered saline, pH 7.4, with 3% bovine serum albumin and 0.05% sodium azide.

基本信息

MDL编号	MFCD06798481
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	200
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	lyophilized powder
species reactivity	rat, human, bovine
technique(s)	indirect immunofluorescence: 8 μg/mL using human brain from Alexander′s diseased patients western blot: 0.5 μg/mL using recombinant bovine phospho-α-B crystallin (Ser59)
UniProt登记号	P02511
运输	dry ice
储存温度	?20℃
Gene Information	human ... CRYAB(1410) rat ... Cryab(25420)