半岛bd体育手机客户端 说明
一般描述
CASP3 (caspase 3) is a cysteine protease belonging to the caspase protein family, and is related to interleukin-1β-converting enzyme (ICE). It is the human homologue ofCaenorhabditis elegansCed-3 protein. This protein forms a key element of apoptosis.
特异性
Detects recombinant human precursor caspase 3 and the 18 kDa form produced during apoptosis.
免疫原
recombinant 18 kDa subunit, amino acids 29-175, of human caspase 3.
生化/生理作用
CASP3 (caspase 3) is an essential protein of apoptosis, which includes multiple death-inducing signals, and caspase 3 functions at the last steps of programmed cell death. This protein is shown to be expressed in esophageal squamous cell carcinoma (ESCC), and its down-regulation is related to increased malignancy and reduced overall survival. Its expression in metastatic lymph nodes (LN) might serve as a marker for poor survival prognosis in patients with resected ESCC and metastasis to LN. Studies in multiple cancers such as, gastric, colorectal, ovarian and cervical cancers show that aberrant expression of this gene is linked with cancer progression and aggressive behavior. It might have potential as a marker to determine the prognosis of the above cancers.
外形
Lyophilized from a 0.2 μm filtered solution in 0.01 M phosphate buffered saline with 5% trehalose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD01321906 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | 84803.111, monoclonal |
| 形式 | lyophilized powder |
| species reactivity | human |
| technique(s) | western blot: 1.0 μg/mL using human Jurkat cells |
| 同位素/亚型 | IgG2b |
| UniProt登记号 | P42574 |
| 储存温度 | ?20℃ |
| Gene Information | human ... CASP3(836) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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