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Cystatin B human

品牌
Sigma-Aldrich
货号
C4249
规格纯度
recombinant, expressed inE. coli
价格
7437.59 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Cystatin B human
CST6
PME
STFB
Liver Thiol Proteinase Inhibitor
CSTB
CPI-B
Stefin B
EPM1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Cystatin B is a member of the type 1 (stefins) superfamily of cystatins. Cystatin B is encoded by theCSTBgene and functions as an intracellular thiol protease inhibitor regulating the activity of members of the papain family and cathepsins B, H, and L. Cystatin B may also protect cellular components from the effects of proteases that leak from lysosomes. Mutations in the CSTB gene are thought to be the primary defect in patients with Progressive Myoclonus Epilepsy (EPM1).

应用

Suitable for use as a cysteine-protease inhibitor. Is tested for suitability as an inhibitor of the enzymatic activity of papain.

生化/生理作用

Cystatin B was shown to interact with the protein RACK-1, β-spectrin and neurofilament light chain NF-L forming a unique multiprotein complex specifically in the cerebellum, confirming its function in the brain.

重悬

Cystatin B should be reconstituted at 100 μg/mL in steile 25 mM Tris pH 7.5 and 100 mM NaCl. Reconstituted product should be stored in single-use aliquots at -70° C and should be stable for at least 3 months.

基本信息

NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 200
重组 expressed inE. coli
描述 contains a N-terminal 7X His-tag
测定 ≥95% (SDS-PAGE)
形式 solid
分子量 apparent mol wt ~13 kDa by SDS-PAGE (reducing)
NCBI登记号 NP_000091
储存温度 ?20℃
Gene Information human ... CSTB(1476)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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