半岛bd体育手机客户端 说明

一般描述

Cullin-1 (Cul1) is encoded by the gene mapped to human chromosome 7q36.1. It is a 85 kDa protein that belongs to the family of cullin protein family containing distinct group of mediators (at least eight cullin members Cul1-8).

免疫原

synthetic peptide located at the C-terminus of human cullin-1 (amino acids 759-776). This sequence is identical in mouse cullin-1 and highly conserved (83% identity) inDrosophilacullin-1.

应用

Anti-Cullin-1 antibody produced in rabbit has been used in western blotting.

生化/生理作用

Cullin 1(CUL1) is a scaffold protein of the ubiquitin E3 ligase Skp1/Cullin1/Rbx1/F-box protein complex, which ubiquitinates a broad range of proteins that are involved in cell-cycle progression, signal transduction and transcription. Cul1 plays an important role in protein degradation and protein ubiquitination. It regulates breast cancer cell proliferation, migration and invasion. Overexpression of Cul1 leads to breast cancer progression. CUL1 promotes human trophoblast cell invasion and dysregulation of its expression may be associated with pre-eclampsia (PE). It may have some role in rheumatoid arthritis (RA) and its response to methotrexate. Cullin1 may act as an important marker for human gastric cancer lymph node metastasis and prognosis.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号	MFCD02096156
NACRES	NA.41

半岛bd体育手机客户端 性质

生物来源	rabbit
质量水平	200
偶联物	unconjugated
抗体形式	affinity isolated antibody
antibody product type	primary antibodies
克隆	polyclonal
形式	buffered aqueous solution
分子量	antigen 85 kDa
species reactivity	mouse, human
technique(s)	western blot: 0.5-1 μg/mL using whole cell extract of human colon carcinoma HCT-116 cell line and whole cell extract of mouse fibroblasts NIH3T3 cell line
UniProt登记号	Q13616
运输	dry ice
储存温度	?20℃
Gene Information	human ... CUL1(8454) mouse ... Cul1(26965)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable