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位置: 首页> 品牌> Sigma-Aldrich> Anti-Anti-Calcium Channel CaV3.2 (α1H) 兔抗

Anti-Calcium Channel CaV3.2 (α1H) antibody produced in rabbit

Anti-Anti-Calcium Channel CaV3.2 (α1H) 兔抗

品牌
Sigma-Aldrich
货号
C1868
规格纯度
affinity isolated antibody, lyophilized powder
价格
9323.92 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Anti-Calcium Channel Ca V3.2 (α1H) antibody produced in rabbit
Anti-Anti-Calcium Channel Ca V3.2 (α1H) 兔抗
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Calcium channel, voltage-dependent, T type, α1H subunit (CACNA1H) is a protein encoded by the CACNA1H gene in humans and is mapped to chromosome 16p13.3. The proteins are membrane protein machinery performing selective permeation of external calcium ions. The α1H channel is sensitive to mibefradil, a nondihydropyridine Ca2+channel blocker. CACNA1H is abundantly expressed in both peripheral and central endings of the primary afferent neurons, regulating neuronal excitability and release of excitatory neurotransmitters.

免疫原

synthetic peptide CHVEGPQERARVAHS corresponding to amino acid residues 581-595 of rat CaV3.2. Epitope location: intracellular loop connecting D1-D2. Mouse, bovine, and canine have 14/15 residues identical; human has 13/15 residues identical.

应用

Anti-Calcium Channel CaV3.2 (α1H) antibody produced in rabbit is suitable for western blotting at a dilution of 1:200 using lysate from the ND7/23 cell line.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

生化/生理作用

Calcium channel, voltage-dependent, T type, α1H subunit (CACNA1H) plays an essential role in regulating neuronal excitability and network oscillations in the brain. Mutations in the gene are associated with various forms of idiopathic generalized epilepsy. Gaining-of-function mutation in CACNA1H increases seizure susceptibility by directly altering neuronal electrical properties and indirectly by changing gene expression. CACNA1H acts as an important mediator of Ca2+entry near the resting membrane potential. It plays a pivotal role in processing of pain signals and may serve as a novel target for development of drugs for the treatment of intractable pain resistant to currently available analgesics. CACNA1H up-regulation is involved in the pathophysiology of inflammatory, neuropathic and visceral pain.

外形

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD09265354
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 lyophilized powder
species reactivity rat
technique(s) western blot: 1:200 using lysate from the ND7/23 cell line
UniProt登记号 Q9EQ60
运输 dry ice
储存温度 ?20℃
Gene Information rat ... Cacna1h(114862)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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