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位置: 首页> 品牌> Sigma-Aldrich> Anti-Calcium Channel (α1Subunit), Pan antibody produced in rabbit

Anti-Calcium Channel (α1Subunit), Pan antibody produced in rabbit

品牌
Sigma-Aldrich
货号
C1103
规格纯度
affinity isolated antibody, lyophilized powder
价格
4122.88 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Anti-Calcium Channel (α 1Subunit), Pan antibody produced in rabbit
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

特异性

The epitope recognized by this antibody is masked by α2 and δ chains; therefore, the antibody binds only after subunit dissociation using Triton X-100 or other detergents.

免疫原

synthetic peptide corresponding to amino acids 1506-1524 of the α1Ssubunit of rat skeletal muscle voltage-gated calcium channel (VGCC, CP15) (Accession P22002) with additional N-terminal cysteine, conjugated to MBS-KLH.

应用

Anti-Calcium Channel (α1 Subunit), Pan antibody produced in rabbit is suitable for immunohistochemistry (using rat heart sections) and western blotting at a dilution of 1:200 using rat brain membranes.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)

生化/生理作用

Calcium channel, voltage-dependent, L type, α1C subunit (Cav1.2) is a protein encoded by the CACNA1C gene in humans and belongs to the family of voltage-gated calcium channels. It serves as the key transducers of cell surface membrane potential changes into local intracellular calcium transients that initiate different physiological events. CACNA1C is a subunit of L-type voltage-dependent calcium channel. It is mapped to chromosome 12p13.3 and is implicated as a susceptibility gene for schizophrenia. CACNA1C is selectively expressed in human TH2 cells and blockage of Cav1.2 channel activation in TH2 cells may represent new strategies to treat allergic diseases in human subjects. Its increased activity is implicated in the pathogenesis of dementia and Alzheimer′s disease (AD).

外形

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose and 0.025% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD02095955
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 100
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 lyophilized powder
species reactivity mouse, rat
technique(s) immunohistochemistry: suitable using rat heart sections (The epitope can be masked by other subunits in some Ca2+channels.)
western blot: 1:200 using rat brain membranes
UniProt登记号 P22002
储存温度 ?20℃
Gene Information mouse ... Cacna1c(12288)
rat ... Cacna1c(24239)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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