半岛bd体育手机客户端 说明

应用

2-Chloro-2′-deoxyadenosine (2-CdA) is a chlorinated purine nucleoside with activity against lymphoproliferative disorders, such as hairy cell leukemia (HCL) and multiple myeloma (MM). 2-CdA resists ADA degradation and is phosphorylated to CdATP in lymphocytes. CdATP incorporation into DNA induces strand breaks and the activation of apoptosis. 2-CdA may also be used in studies involving the inhibition of DNA polymerase(s).
Cladribiane, like fludarabine, is a prodrug that is must be phosphorylated intracellularly to the monophosphate by the nuclear/cytosol enzyme deoxycytidine kinase (dCK) and possibly by the mitochondrial enzyme deoxyguanosine kinase (dGK).
Cladribiane, like fludarabine, is a prodrug that is must be phosphorylated intracellularly to the monophosphate by the nuclear/cytosol enzyme deoxycytidine kinase (dCK) and possibly by the mitochondrial enzyme deoxyguanosine kinase (dGK). Clinically used for treatment of hairy cell leukemia, chronic lymphocytic leukemia and other indolent leukemias.

包装

10 mg in poly bottle
25 mg in glass bottle

生化/生理作用

Deoxyadenosine analog resistant to adenosine deaminase; antileukemic with immunosuppressive activity

基本信息

经验(实验)分子式	C10H12ClN5O3
分子量	285.69
MDL编号	MFCD00153939
PubChem化学物质编号	24892693
NACRES	NA.51

半岛bd体育手机客户端 性质

质量水平	200
测定	≥98% (HPLC)
形式	powder or crystals
储存温度	2-8℃
SMILES string	Nc1nc(Cl)nc2n(cnc12)[C@H]3C[C@H](O)[C@@H](CO)O3
InChI	1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1
InChI key	PTOAARAWEBMLNO-KVQBGUIXSA-N
Gene Information	human ... NP(4860) rat ... Adora1(29290), Adora2a(25369), Adora3(25370)

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H341 - H361fd - H372
预防措施声明	P201 - P202 - P260 - P264 - P270 - P301 + P310
危险分类	Acute Tox. 3 Oral - Muta. 2 - Repr. 2 - STOT RE 1
储存分类代码	6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges