Cathepsin G from human leukocytes

半岛bd体育手机客户端 说明

一般描述

Cathepsin G from human leukocytes is a neutral proteinase secreted by neutrophil granulocytes. It belongs to the family of serine proteases. Cathepsin G is a glycoprotein, which contains 1% carbohydrate. The gene is located on human chromosome 14q12.

应用

Cathepsin G from human leukocytes has been used to determine protease sensitivity. It has also been used for the stimulation and staining of dendritic cells and macrophage.

生化/生理作用

Cathepsin G from human leukocytes degrades various proteins, such as elastin, collagen, fibrinogen and immunoglobin. It may be implicated in muscle catabolism. Cathepsin G is involved in the activation or inactivation of protein hormones and the inactivation of plasma proteinase inhibitors. It alters the cytoskeleton, enhances the permeability of vascular endothelial cells and the chemotaxis of inflammatory cells. Cathepsin G is associated with autoimmunity and cancer. It exhibits chymotrypsin and trypsin like activity. Cathepsin G modulates neutrophil effector functions.
Cathepsin G has pro-apoptotic activity and can activate caspasesin vitro.

单位定义

One unit will release one nanomole ofp-nitroaniline per second from N-succinyl-Ala-Ala-Pro-Phep-nitroanilide at pH 7.5 at 37 ℃.

外形

Lyophilized from 0.5 M pyridinium acetate, pH 5.3.

基本信息

酶学委员会(EC)编号	3.4.21.20 ( BRENDA | IUBMB )
MDL编号	MFCD00130750
NACRES	NA.32

半岛bd体育手机客户端 性质

形式	lyophilized powder
质量水平	200
specific activity	≥60 units/mg protein (Bradford)
分子量	23-30 kDa
UniProt登记号	P08311
运输	dry ice
储存温度	?20℃
Gene Information	human ... CTSG(1511)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable