Anti-alpha-Synuclein (aa 121-125) Antibody, clone Syn211 (Ascites Free)

半岛bd体育手机客户端 说明

一般描述

Alpha-synuclein is encoded by the SNCA gene (also known as NACP, PARK1) in human. There are two other known synuclein family members, beta- and gamma-synuclein. Interest in synuclein research started with the discovery of alpha-synuclein mutation in several families with autosomal dominant Parkinson′s disease (PD). Alpha-synuclein is abundantly expressed in the brain and is found in a classic amyloid fibril form within the intra-neuronal Lewy body deposits of PD. The physiological function of synucleins is not well understood, but appears to involve membrane interactions, and in particular reversible binding to synaptic vesicle membranes. Contradictory evidences regarding inhibitory action of alpha-synuclein against phospholipase D (PLD) have been reported (PMID 11821392 & 19146388). Clone Syn211, Cat. No. 36-008-C detects epitope in the region from amino acid 121 to 125 and has been used together with clone LB509, Cat. No. MABN824, to characterize the digestion pattern of different forms of in vitro prepared alpha-synclulein aggregates (Guo, J.L., et al. 2013; PMID 23827677).

免疫原

Epitope: alpha-syn 121-125
Conjugated recombinant protein corresponding to human alpha-Synuclein.

应用

Immunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected alpha-Synuclein in human cerebral cortex and human kidney tissue.
Western Blotting Analysis: A representative lot detected alpha-Synuclein in Synucleinopathy brains (Guo, J.L., et al. (2013). Cell. 154:103-117).
Anti-alpha-Synuclein (aa 121-125) Antibody, clone Syn211 (Ascites Free) is an antibody against alpha-Synuclein for use in Immunohistochemistry and Western Blotting.

质量

Evaluated by Western Blotting in human brain tissue lysate.

Western Blotting Analysis: 1.0 ?g/mL of this antibody detected alpha-Synuclein in 10 ?g of human brain tissue lysate.

目标描述

~15 kDa observed

外形

Protein G Purified
Format: Purified

储存及稳定性

Stable for 1 year at 2-8°Cfrom date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	Syn211, monoclonal
species reactivity	human
technique(s)	immunohistochemistry: suitable western blot: suitable
同位素/亚型	IgG1κ
NCBI登记号	NP_000336
UniProt登记号	P37840
运输	wet ice
Gene Information	human ... SNCA(6622)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable