CX546

半岛bd体育手机客户端 说明

一般描述

CX546, a benzoylpiperidine derivative ampakine is an analog of CX516.

应用

CX546 has been used as positive allosteric modulator for the glutamatergic receptor α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in mice.

包装

10, 50 mg in glass bottle

生化/生理作用

CX546 has antipsychotic functionality and has the potential to treat schizophrenia. It improves the defects associated with the prepulse inhibition (PPI) and latent inhibition (LI) in mice lacking metabotropic glutamate receptor type 5 (mGluR5). Additionally, CX546 potentiates synaptic plasticity, elicits neuroprotection and promotes the neurotrophin expression.
Positive AMPA glutamate receptor modulator.

注意

Photosensitive

基本信息

经验(实验)分子式	C14H17NO3
分子量	247.29
MDL编号	MFCD01860868
PubChem化学物质编号	24277960
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
储存条件	protect from light
颜色	white to off-white
溶解性	DMSO: ≥10 mg/mL
储存温度	2-8℃
SMILES string	O=C(N1CCCCC1)c2ccc3OCCOc3c2
InChI	1S/C14H17NO3/c16-14(15-6-2-1-3-7-15)11-4-5-12-13(10-11)18-9-8-17-12/h4-5,10H,1-3,6-9H2
InChI key	LJUNPHMOGNFFOS-UHFFFAOYSA-N
Gene Information	human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)