Interleukin-12 Protein, Recombinant human

半岛bd体育手机客户端 说明

一般描述

Interleukin-12 (IL-12) is a potent regulator of cell mediated immune responses and it induces IFN-gamma production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes, and connective tissue type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-gamma producing Th1 cells. Human IL-12 is a disulfide linked heterodimeric protein with a molecular weight of 75 kDa comprised of disulfide-bonded 35 kDa (p35) and 40 kDa (p40) subunits.
Product Source: CHO cells (Chinese Hamster Ovarian cells)

应用

For most in vitro applications, IL-12 exerts its biological activity in the concentration range of 1.0 to 10.0 ng/mL.

生化/生理作用

The ED50 as determined by the induction of IFN-g production from NK cells co-stimulated with IL-18 was ≤ 1.0 ng/mL

外形

The sterile filtered solution was lyophilized from 0.5X PBS pH 7.2

储存及稳定性

The lyophilized IL-12, though stable at room temperature, is best stored desiccated below 0°C. Reconstitute with sterile water to a concentration of 0.2 mg/mL. Reconstituted IL-12 should be stored in undiluted aliquots at -20°C for up to 6 months.

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss

32160405

半岛bd体育手机客户端 性质

质量水平	100
生物来源	human
测定	>98% (SDS-PAGE and HPLC)
specific activity	≥1.0 x 10E6 U/mg
manufacturer/tradename	Chemicon?
technique(s)	cell culture | mammalian: suitable
杂质	<0.1 ng/μg endotoxin (of IL-12; 1EU/μg)
input	sample type hematopoietic stem cell(s)
UniProt登记号	P29459 P29460
运输	dry ice

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3