半岛bd体育手机客户端 说明

应用

Carmofur has been used as an inhibitor of acid ceramidase to study its effects on glucosylsphingosine (GlcSph) production in human embryonic kidney 293T (HEK293T) cells. It has also been used as an inhibitor of acid ceramidase to study its effects on acid‐mediated hydrolysis of ceramide which kicks-in consumption and the generation of sphingosine .

包装

10, 50 mg in glass bottle

生化/生理作用

Carmofur is a derivative of fluorouracil, an antimetabolite used as an antineoplastic agent.
Carmofur acts as an inhibitor of fatty acid amide hydrolase (FAAH),N-acylethanolamine acid amidase (NAAA) and acid ceramidase (ASAH1). Carmofur has a therapeutic activity against colorectal and cervical cancer. It can inhibit the severe acute respiratory syndrome (SARS)-CoV-2 main protease (M^pro)in vitro.

基本信息

经验(实验)分子式	C11H16FN3O3
分子量	257.26
MDL编号	MFCD00866284
PubChem化学物质编号	329774890
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to off-white
溶解性	DMSO: >15 mg/mL
储存温度	2-8℃
SMILES string	CCCCCCNC(=O)N1C=C(F)C(=O)NC1=O
InChI	1S/C11H16FN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18)
InChI key	AOCCBINRVIKJHY-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H301 - H361
预防措施声明	P201 - P301 + P310 + P330
危险分类	Acute Tox. 3 Oral - Repr. 2
储存分类代码	6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable