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位置: 首页> 品牌> Sigma-Aldrich> Chlorzoxazone

Chlorzoxazone

品牌
Sigma-Aldrich
CAS
95-25-0
货号
C4397
包装型号
规格纯度
价格
1086.96 *本价格含增值税费
促销
服务
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  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
95-25-0
Chlorzoxazone
5-Chloro-2-hydroxybenzoxazole
5-Chloro-2(3H)-benzoxazolone
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

Chlorzoxazone may be used:

  • as a calcium-activated potassium (KCa) channel activator in patch-clamp electrophysiology to test its effect on dendritic hyperexcitability
  • as a substrate for cytochrome P450 2E1 (CYP2E1) enzyme in cultured human hepatocytes
  • as a benzimidazolone compound to test its effect on epithelial sodium (Na+) transport

包装

25, 100 g in poly bottle

生化/生理作用

Chlorzoxazone inhibits the multisynaptic reflex arcs primarily in the spinal cord and brain subcortical areas. It is an activator of calcium activated potassium channels and may contribute to the aortic artery relaxation in mice. Chlorzoxazone also activates the calcium-activated potassium (KCa) channel and small conductance calcium-activated potassium channels (SK). It is metabolized by cytochrome P450 2E1 (CYP2E1) and serves as a probe for monitoring this enzyme function.
Chlorzoxazone is a skeletal muscle relaxant.

特点和优势

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

基本信息

经验(实验)分子式 C7H4ClNO2
分子量 169.57
EC 号 202-403-9
MDL编号 MFCD00005717
PubChem化学物质编号 24277702
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (TLC)
形式 powder
颜色 white to off-white
mp 191-192 ℃ (lit.)
溶解性 DMSO: 50 mg/mL, clear
创始人 Johnson & Johnson
储存温度 room temp
SMILES string Clc1ccc2OC(=O)Nc2c1
InChI 1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10)
InChI key TZFWDZFKRBELIQ-UHFFFAOYSA-N
Gene Information human ... KCNN4(3783)

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H302 - H315 - H319 - H335
预防措施声明 P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338
危险分类 Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官 Respiratory system
储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 dust mask type N95 (US), Eyeshields, Gloves

Sigma-Aldrich

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