半岛bd体育手机客户端 说明
应用
Acitretin, a retinoid that binds to nuclear receptors and regulates gene expression, is a potent activator of the α-secretase ADAM10 gene expression and apoptosis inducer via the CD95 signalling pathway. Acitretin is a systemic retinoid drug used in the treatment of severe psoriasis.
生化/生理作用
Synthetic retinoid that is a metabolite of etretinate. Preferentially binds to cellular retinoic acid binding proteins (CRABPs).
其他说明
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 44707.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
基本信息
| 经验(实验)分子式 | C21H26O3 |
| 分子量 | 326.43 |
| EC 号 | 259-474-4 |
| MDL编号 | MFCD00866632 |
| PubChem化学物质编号 | 57650239 |
| NACRES | NA.25 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98.0% (HPLC) |
| 形式 | powder |
| SMILES string | COc1cc(C)c(\C=C\C(C)=C\C=C\C(C)=C\C(O)=O)c(C)c1C |
| InChI | 1S/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4/h7-13H,1-6H3,(H,22,23)/b9-7+,11-10+,14-8+,15-12+ |
| InChI key | IHUNBGSDBOWDMA-AQFIFDHZSA-N |
| Gene Information | human ... RARA(5914), RARB(5915), RARG(5916), RXRA(6256), RXRB(6257), RXRG(6258) |
安全信息
| 象形图 |    |
| 警示用语： | Danger |
| 危险声明 | H315 - H319 - H360 - H410 |
| 预防措施声明 | P201 - P273 - P302 + P352 - P305 + P351 + P338 - P308 + P313 |
| 危险分类 | Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 |
| 储存分类代码 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
Sigma-Aldrich
m.cnreagent.com
