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位置: 首页> 品牌> Sigma-Aldrich> Anti-CD4 (human), PerCP, clone SK3 Antibody

Anti-CD4 (human), PerCP, clone SK3 Antibody

品牌
Sigma-Aldrich
货号
MABF172B
规格纯度
clone SK3, from mouse, Peridinin-Chlorophyll-Protein Complex
价格
3673.88 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Anti-CD4 (human), PerCP, clone SK3 Antibody
T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3, CD antigen CD4, CD4
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The SK3 antibody reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells. The SK3 antibody is widely used as a phenotypic marker for human CD4 expression, and has been reported to be cross-reactive with Rhesus and Cynomolgus CD4. This antibody does not block binding of alternative clone RPA-T4, suggesting that they recognize different epitopes.

免疫原

Immunogen information for this antibody is proprietary information.

应用

Anti-CD4 (human), PerCP, clone SK3 Antibody is an antibody against CD4 for use in Flow Cytometry.
Research Sub Category
Immunoglobulins & Immunology
Research Category
Inflammation & Immunology

质量

This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.06 μg from a representative lot detected CD4 in one million human peripheral blood lymphocytes.

外形

Purified Mouse monoclonal containing 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.
Purified by size-exclusion chromatography

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.
Note: It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
偶联物 Peridinin-Chlorophyll-Protein Complex
抗体形式 purified antibody
antibody product type primary antibodies
克隆 SK3, monoclonal
species reactivity human
technique(s) flow cytometry: suitable
UniProt登记号 P01730

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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