半岛bd体育手机客户端 说明
一般描述
BCAEC have been used to demonstrate that the stress hormone cortisol inhibits NO synthase and Ca2+ mobilization leading to decreased NO release by endothelial cells, resulting in increased arterial contraction and decreased blood flow (Rogers, 2002). Similar action mechanism were determined for cocaine effects on arteries (He, 2005). Additionally it was found that cocaine-induced apoptosis of endothelial cells is mediated by attenuation of NO production, down-regulation of Bcl-2 and translocation of Bac to the mitochondria, followed by release of cytochrome c and activation of caspase 9 and caspase 3 (He, 2000, 2001). BCAEC were also used to determine that diabetes-related vascular dysfunction is mediated by decreased NO production due to direct substrate competition between NO synthase and arginase whose activity is markedly increased in many conditions characterized by vascular dysfunction (Romero, 2008). BCAEC were also used to evaluate novel mesh-like materials for their suitability for biomedical applications (Nair, 2004).
细胞系来源
Artery
应用
cardiovascular function, angiogenesis, vascular biology, regulation of coronary blood flow, cardiac functions, effects of vaso-dilators, coagulation, fibrinolysis, vessel wall tone, cytokine production
组分
Bovine Endothelial Cell Growth Medium containing 10% FBS & 10% DMSO
制备说明
传代培养常规
Please refer to the BCAEC Culture Protocol.
基本信息
| NACRES | NA.81 |
半岛bd体育手机客户端 性质
| 生物来源 | bovine coronary artery (USDA-inspected cattle) |
| 质量水平 | 100 |
| 包装 | pkg of 500,000 cells |
| 生长模式 | Adherent |
| 核型 | 2n = 60 |
| 形态学 | Endothelial |
| technique(s) | cell culture | mammalian: suitable |
| 相关疾病 | cardiovascular diseases |
| 储存温度 | ?196℃ |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
