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Bcl-w (Minus C-Terminus) human

品牌
Sigma-Aldrich
货号
B1059
规格纯度
>95% (SDS-PAGE), recombinant, expressed inE. coli, buffered aqueous glycerol solution
价格
12348 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
Bcl-w (Minus C-Terminus) human
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

This recombinant Bcl-w lacks the mitochondrial targeting sequence but maintains the ability to neutralize pro-apoptotic Bcl-2 family members.

生化/生理作用

Like Bcl-2 and Bcl-x, the Bcl-w protein promotes cell survival, in contrast to other close homologues, Bax and Bak, which facilitate cell death. Bcl-w is an anti-apoptotic member of the Bcl-2 family that prevents release of cytochrome c from the mitochondrial intermembrane space into the cytosol. It is required for normal sperm maturation. Natural Bcl-w contains a C-terminal mitochondrial targeting sequence.

外形

Supplied as a 0.2 μm filtered solution in 25 mM HEPES, pH 7.5, 0.1 M KCl, and 10% glycerol.

分析说明

Measured by its ability to inhibit caspase-8-cleaved human BID-mediated release of cytochrome c from isolated mouse liver mitochondria using ELISA.

基本信息

MDL编号 MFCD03846039
NACRES NA.32

半岛bd体育手机客户端 性质

质量水平 200
重组 expressed inE. coli
测定 >95% (SDS-PAGE)
形式 buffered aqueous glycerol solution
分子量 18 kDa by SDS-PAGE
UniProt登记号 Q92843
运输 wet ice
储存温度 ?20℃
Gene Information human ... BCL2L2(599)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, type N95 (US)

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