BL-1249

半岛bd体育手机客户端 说明

一般描述

BL-1249 is a non-steroid anti-inflammatory drug and an inhibitor of the cyclooxygenase (COX) enzyme.

应用

BL-1249 has been used:

• as an activator of mechano-gated K2P channel in contracted mouse ileum and colon tissues
• as a TWIK related potassium channel (TREK2) modulator and in U-2 OS osteosarcoma cell line
• as a TREK1 and TREK2 activator in mice.

包装

10, 50 mg in glass bottle

生化/生理作用

BL-1249 also activates TWIK related potassium channel 2 (TREK2). It interacts with K2P channel at the negatively charged activator site and modulates channel opening.
BL-1249 is a putative activator of potassium TREK-1 channel.

特点和优势

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式	C17H17N5
分子量	291.35
MDL编号	MFCD08276915
PubChem化学物质编号	24724415
NACRES	NA.77

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
储存条件	protect from light
颜色	pink to brown
溶解性	DMSO: ~17.5 mg/mL H2O: insoluble
储存温度	?20℃
SMILES string	C1CCc2c(C1)cccc2Nc3ccccc3-c4nnn[nH]4
InChI	1S/C17H17N5/c1-2-8-13-12(6-1)7-5-11-15(13)18-16-10-4-3-9-14(16)17-19-21-22-20-17/h3-5,7,9-11,18H,1-2,6,8H2,(H,19,20,21,22)
InChI key	YYNRZIFBTOUICE-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H315 - H319 - H335 - H413
预防措施声明	P273 - P302 + P352 - P305 + P351 + P338
危险分类	Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官	Respiratory system
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves