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位置: 首页> 品牌> Sigma-Aldrich> Anti-Apolipoprotein(a) Antibody, clone LPA4 Antibody, Biotin Conjugate

Anti-Apolipoprotein(a) Antibody, clone LPA4 Antibody, Biotin Conjugate

品牌
Sigma-Aldrich
货号
MABS1284-B
规格纯度
clone LPA4, from mouse, biotin conjugate
价格
4689.25 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-Apolipoprotein(a) Antibody, clone LPA4 Antibody, Biotin Conjugate
Apo(a), Lp(a)
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Apolipoprotein(a) (UniProt P08519; also known as Apo(a), Lp(a)) is encoded by the LPA gene (Gene ID 4018) in human. Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It is synthesized with a signal peptide (aa 1-19) that is subsequently cleaved off. Lipoprotein (a)/Lp(a) is composed of Apo(a) covalently bound to apolipoprotein B-100/ApoB via a single disulfide bond on kringle (K)IV type 9 (KIV9) to a site near ApoB low density lipoprotein (LDL) receptor-binding site. Structurally, Apo (a) contains ten subtypes of KIV sequences, with the KIV2 subtype present in multiple identical repeats, followed by a KV sequence and an inactive protease domain. Elevated levels of Lp(a) are considered as a risk factor in the development of cardiovascular diseases and peripheral arterial disease. Lp(a) is a preferential lipoprotein carrier of oxidized phospholipids (OxPLs) and circulating levels of oxidized LDL are strongly associated with angiographically documented coronary artery disease. Apo(a) is known to be proteolytically cleaved. Apo(a) fragments accumulate in atherosclerotic lesions, where they may promote thrombogenesis.

特异性

Clone LPA4 detects Apolipoprotein(a) in human and non-human primates.

免疫原

Human Lipoprotein a (Lp(a)).

应用

Research Category
Signaling
ELISA Analysis: A representative lot detected Apolipoprotein(a) in ELISA applications (Pedersen, T.X., et. al. (2010). J Lipid Res. 51(10):2967-75; Leibundgut, G., et. al. (2013). J Lipid Res. 54(10):2815-30).

ELISA Analysis: 0.1 ?g/mL from a representative lot detected Apolipoprotein(a) in Patient Lp(a) Plasma sample (Courtesy of Dr. Sotirios Tsimikas, M.D., University of California at San Diego, USA).

Immunoprecipitation Analysis: A representative lot detected Apolipoprotein(a) in Immunoprecipitation applications (Tsimikas, S., et. al. (2004). Circulation. 109(25):3164-70).

Western Blotting Analysis: A representative lot detected Apolipoprotein(a) in Western Blotting applications (Leibundgut, G., et. al. (2013). J Lipid Res. 54(10):2815-30).

Anti-Apolipoprotein(a), clone LPA4, Biotin Conjugate, Cat. No. MABS1284-B, is a mouse monoclonal antibody that detects Apolipoprotein (a)/Apo(a)/Lp(a) in human and non-human primates and has been tested for use in ELISA, Immunoprecipitation, and Western Blotting.

质量

N/A

目标描述

501.32 kDa calculated for Apolipoprotein A

外形

Protein G purified
Purified mouse monoclonal antibody IgG1 in PBS with 1.5% BSA and 0.1% sodium azide.

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss 32160702
NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 100
生物来源 mouse
偶联物 biotin conjugate
抗体形式 purified immunoglobulin
antibody product type primary antibodies
克隆 LPA4, monoclonal
species reactivity nonhuman primates, human
technique(s) ELISA: suitable
immunoprecipitation (IP): suitable
western blot: suitable
同位素/亚型 IgG1κ
UniProt登记号 P08519
运输 ambient

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