半岛bd体育手机客户端 说明
一般描述
Effective concentration: 1-100 ?M.
A reversible protease inhibitor produced by actinomycetes. Inhibits cathepsin A and B as well as papain, and trypsin-like serine proteases. Acts by forming a hemiacetal adduct between the aldehyde group of the inhibitor and the active proteinase. Effective at concentrations range from 1 to 100 ?M.
Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca2+-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975). Inhibits trypsin-like serine proteases, papain and some cysteine proteases (IC50= 300 ?M).
包装
10 mg in Plastic ampoule
生化/生理作用
Target IC50: 300 ?M against trypsin-like serine proteases, papain and some cysteine proteases; Effective concentration: 1-100 ?M
Product does not compete with ATP.
Cell permeable: no
Reversible: yes
Primary Target
trypsin-like serine proteases, papain, and some cysteine proteases
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
其他说明
Lyupina, Y.V., et al. 1996.Eur. J. Pharmacol.304,23.
Ichikawa, S., et al. 1985.J. Reprod. Fertil.73,385
Umezawa, H. 1976.Methods Enzymol.55,678.
Suda, H., et al. 1972.J. Antibiot.(Tokyo)25,263.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C27H44N10O6· 2HCl |
| 分子量 | 677.62 |
| MDL编号 | MFCD00135957 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥97% (HPLC) |
| 形式 | powder |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
| 颜色 | white |
| 溶解性 | water: 1 mg/mL DMSO: 5 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
| InChI | 1S/C27H44N10O6.2ClH/c1-16(2)21(34-18(15-38)10-6-12-32-25(28)29)23(40)37-22(39)19(11-7-13-33-26(30)31)35-27(43)36-20(24(41)42)14-17-8-4-3-5-9-17;;/h3-5,8-9,15-16,18-21,34H,6-7,10-14H2,1-2H3,(H,41,42)(H4,28,29,32)(H4,30,31,33)(H2,35,36,43)(H,37,39,40);2*1H/t18?,19-,20?,21-;;/m0../s1 |
| InChI key | GXQPAKIVOCLCHD-BXLPLHKWSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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