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IL-1ALPHA human

人 IL-1α

品牌
Sigma-Aldrich
货号
SRP3310
规格纯度
Animal-component free, recombinant, expressed inE. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
价格
4955.05 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
IL-1ALPHA human
Hematopoietin-1
Lymphocyte-activating factor (LAF)
Endogenous Pyrogen (EP)
人 IL-1α
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

IL-1α (interleukin) is one of the three isoforms of IL-1, the other two being IL-1β and IL-1Rα. It is a proinflammatory macrophage cytokine. IL-1α is producedde novoand can either be actively secreted or can be released passively by apoptotic cells. This gene is localized to human chromosome 2q13–2q14.1.
Recombinant human IL-1α is an 18.0 kDa protein containing 159 amino acid residues.

生化/生理作用

IL-1α (interleukin) and IL-1β bind with IL-1 receptor and function as proinflammatory cytokines, whereas IL-1Rα competes to bind with IL-1R but is not proinflammatory. IL-1α can function as an intracrine molecule or as a transcription factor. IL-1 plays a major role in ischemic brain damage, as the inactivation of both IL-1α and IL-1β lead to significant suppression in brain injury. However, inactivation of only IL-1α does not have much influence on overall damage due to some compensatory modifications in the IL-1 system. A hospital-based case-control study showed that rs3783553 variant in this gene is linked with reduced risk of breast cancer. Tumor cell production of IL-1α helps their transmigration across the endothelium, and the expression of IL-1α is linked with distant metastasis in patients with head and neck squamous cell carcinoma.

外形

Lyophilized from 3.2 mM Tris, pH 8.3 + 16 mM NaCl.

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed inE. coli
测定 ≥98% (HPLC)
≥98% (SDS-PAGE)
形式 lyophilized
效能 ≤0.001 ng/mL
分子量 18.0 kDa
包装 pkg of 10 μg
杂质 endotoxin, tested
UniProt登记号 P01583
运输 wet ice
储存温度 ?20℃
Gene Information human ... IL1A(3552)

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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