半岛bd体育手机客户端 说明
一般描述
IL-1α (interleukin) is one of the three isoforms of IL-1, the other two being IL-1β and IL-1Rα. It is a proinflammatory macrophage cytokine. IL-1α is producedde novoand can either be actively secreted or can be released passively by apoptotic cells. This gene is localized to human chromosome 2q13–2q14.1.
Recombinant human IL-1α is an 18.0 kDa protein containing 159 amino acid residues.
生化/生理作用
IL-1α (interleukin) and IL-1β bind with IL-1 receptor and function as proinflammatory cytokines, whereas IL-1Rα competes to bind with IL-1R but is not proinflammatory. IL-1α can function as an intracrine molecule or as a transcription factor. IL-1 plays a major role in ischemic brain damage, as the inactivation of both IL-1α and IL-1β lead to significant suppression in brain injury. However, inactivation of only IL-1α does not have much influence on overall damage due to some compensatory modifications in the IL-1 system. A hospital-based case-control study showed that rs3783553 variant in this gene is linked with reduced risk of breast cancer. Tumor cell production of IL-1α helps their transmigration across the endothelium, and the expression of IL-1α is linked with distant metastasis in patients with head and neck squamous cell carcinoma.
外形
Lyophilized from 3.2 mM Tris, pH 8.3 + 16 mM NaCl.
重悬
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.
基本信息
NACRES | NA.32 |
半岛bd体育手机客户端 性质
生物来源 | human |
重组 | expressed inE. coli |
测定 | ≥98% (HPLC) ≥98% (SDS-PAGE) |
形式 | lyophilized |
效能 | ≤0.001 ng/mL |
分子量 | 18.0 kDa |
包装 | pkg of 10 μg |
杂质 | endotoxin, tested |
UniProt登记号 | P01583 |
运输 | wet ice |
储存温度 | ?20℃ |
Gene Information | human ... IL1A(3552) |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich