您好,欢迎来到半岛电竞官方网址 ! [ 登录] [ 免费注册]
半岛电竞官方网址
位置: 首页> 品牌> Sigma-Aldrich> Anagrelide hydrochloride

Anagrelide hydrochloride

品牌
Sigma-Aldrich
CAS
58579-51-4
货号
SML0846
规格纯度
≥98% (HPLC)
价格
1396.09 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
58579-51-4
Anagrelide hydrochloride
6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-2(3H)-one hydrochloride
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Anagrelide belongs to the imidazo[2,1-b]quinazolin-2-one series of compounds.
Download the CofA, SDS and IFU specific to your product lot and format
Fab fragments from polyclonal anti-fluorescein antibodies, conjugated to alkaline phosphatase.
After immunization with fluorescein, the sheep IgG was purified by ion exchange chromatography and the specific IgG was isolated by immunosorption. The Fab fragments obtained by papain digestion were purified by gel filtration, conjugated with alkaline phosphatase, and stabilized in 50 mM triethanolamine buffer, 3 M NaCl, 1 mM MgCl2, 0.1 mM ZnCl2, 1% bovine serum albumin (w/v), pH 7.6.
Clone: polyclonal
Ig class: sheep IgG, Fab fragments

包装

10, 50 mg in glass bottle

生化/生理作用

Anagrelide is a phosphodiesterase inhibitor with antiplatelet activity (IC50= 36 nM for inhibition of phosphodiesterase-III). Anagrelide inhibits the maturation of megakaryocytes into platelets, reducing both megakaryocyte hyperproliferation and differentiation. As a drug, anagrelide is antithrombocythemic used for the treatment of overproduction of blood platelets.
Anagrelide is a phosphodiesterase inhibitor with antiplatelet activity.
In human and animals, anagrelide has an inhibitory effect on platelet aggregation. Small doses of anagrelide can generate thrombocytopenia. Anagrelide is not advised during pregnancy. It is effectively used in the treatment of essential thrombocytosis.

特点和优势

This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

基本信息

经验(实验)分子式 C10H7Cl2N3O · HCl
分子量 292.55
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
储存条件 desiccated
颜色 white to beige
溶解性 DMSO: 1 mg/mL, clear (warmed)
储存温度 2-8℃
InChI 1S/C10H7Cl2N3O.ClH/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7;/h1-2H,3-4H2,(H,13,14,16);1H
InChI key TVWRQCIPWUCNMI-UHFFFAOYSA-N

安全信息

象形图 GHS08
警示用语: Warning
危险声明 H351 - H361d - H413
预防措施声明 P202 - P273 - P280 - P308 + P313 - P405 - P501
危险分类 Aquatic Chronic 4 - Carc. 2 - Repr. 2
储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

推荐半岛bd体育手机客户端
Baidu
map