ZAP-70 Tyrosine Kinase human

半岛bd体育手机客户端 说明

应用

Human ZAP-70 Tyrosine Kinase was used for mapping the phosphorylation sites on LAT (linker for activation of T cells) for investigating the mechanism of activation of signalling proteins in T cells.

生化/生理作用

ZAP-70 Tyrosine Kinase is a protein belongs to Syk family and is essential for T cell activation. It facilitates the upregulation of Fas ligand in activation-induced T cell apoptosis. Additionally, it also plays a pivotal role in LFA-1-dependent T Cell Migration.
ZAP-70 is protein tyrosine kinase of the Syk family that is localized exclusively to the cytosol of T cells and natural killer cells. It is required for T cell activation. It is activated by Lck-mediated phosphorylation of its tyrosine residues.

单位定义

One unit will phosphorylate 1 nmol polyglutamic acid:tyrosine per min at 37 ℃ at pH 7.0.

外形

Solution in 25 mM HEPES, pH 7.5, containing 150 mM NaCl, 0.5 mM DTT, and 50% glycerol.

基本信息

MDL编号	MFCD03459122
NACRES	NA.32

半岛bd体育手机客户端 性质

质量水平	200
重组	expressed in baculovirus infected insect cells (Histidine tagged)
测定	≥90% (SDS-PAGE)
形式	buffered aqueous glycerol solution
specific activity	≥150 U/mg
分子量	70 kDa
UniProt登记号	P43403
运输	dry ice
储存温度	?70℃
Gene Information	human ... ZAP70(7535)

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 1