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IL-13 Variant human

品牌
Sigma-Aldrich
货号
SRP3076
规格纯度
recombinant, expressed inE. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
价格
4275.92 *本价格含增值税费
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半岛bd体育手机客户端 名称:
IL-13 Variant human
interleukin 13
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

IL13 (interleukin 13) is a classic cytokine produced by Th2(T-helper) cells. This gene is localized to human chromosome 5q31, and is composed of four exons and three introns.
Recombinant human IL-13 is a 12.5 kDa protein consisting of 114 amino acid residues.

应用

IL-13 variant human has been used for the treatment of THP1 monocytes, along with with IL-4 and phorbol myristate acetate (PMA), to study the ability of SFN (sulforaphane) to induce THP1 differentiation into M2 macrophage cells.

生化/生理作用

IL13 (interleukin 13) is up-regulated during parasitic infections, and participates in host′s protective immunity againstSchistosoma japonicum. This protein promotes eosinophil activation resulting in elevated specific IgE against adult and larval antigens. During acute infection it promotes egg expulsion through increased intestinal contractility. It acts as a liver protective agent where it promotes formation of liver granulomas in a CD4+T cell-mediated manner, which results in liver fibrosis. In airway disorders, such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis lung disease, IL13 promotes the formation of airway goblet cells, resulting in excess mucus secretion, which in turn, is regulated by IL13-activated autophagy. In adult subjects with ever-asthma, SNP (single nucleotide polymorphism) rs848 in this gene is linked with symptom severity.

序列

MSPGPVPPST ALRELIEELV NITQNQKAPL CNGSMVWSIN LTAGMYCAAL ESLINVSGCS AIEKTQRMLS GFCPHKVSAG QFSSLHVRDT KIEVAQFVKD LLLHLKKLFR EGQFN

外形

Lyophilized from 10 mM Sodium Citrate, pH 4.0.

重悬

Centrifuge the vial prior to opening. Reconstitute in 20 mM Acetic Acid to a concentration of 0.1-0.5 mg/ml. Note: Allow the reconstituted vial to sit at 4℃ for at >2 hours before use. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed inE. coli
测定 ≥98% (HPLC)
≥98% (SDS-PAGE)
形式 lyophilized
分子量 12.6 kDa
包装 pkg of 10 μg
technique(s) cell culture | mammalian: suitable
杂质 <0.1 EU/μg endotoxin, tested
颜色 white to off-white
UniProt登记号 P35225
运输 wet ice
储存温度 ?20℃
Gene Information human ... IL13(3596)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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