Ephrin-A1/Fc Chimera from mouse

半岛bd体育手机客户端 说明

生化/生理作用

EphA1 (ephrin receptor A1) plays an essential role in development, and is involved in the guidance of axonal and cell migration in nervous system. Disruption of ephrin signaling might be involved in the tumorigenesis of clear cell renal cell carcinoma, and absence of EphA1 has a favorable prognosis in the same. It might also be involved in the tumorigenesis and progression of prostate cancer, and might have potential as a marker for prognosis, as well as a therapeutic target. Studies show that it reduces the risk of Alzheimer′s disease, by hindering pathological changes in brain areas such as, hippocampus, lateral occipitotemporal and inferior temporal gyri. In esophageal squamous cells, it acts as differentiation marker. Its expression is elevated in esophageal squamous cell carcinoma, and this relates to advanced stage and metastasis to lymph node.
Member of ephrin ligand family that binds Eph receptor tyrosine kinases (EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7 and EphB1). Involved in pattern formation and morphogenesis. Ephrin-A1 can be detected on fetal osteoblasts, odotoblasts, chondrocytes, and squamous epithelium. Ephrin-A1 is expressed during embryonic vasculogenesis and during tumor-induced angiogenesis.

其他说明

Extracellular domain of mouse ephrin-A1 (amino acids 1-182) fused to the C-terminal 6X histidine-tagged Fc region of human IgG.

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

分析说明

The biological activity is measured by its ability to bind recombinant mouse EphA2/Fc in ELISA.

基本信息

MDL编号	MFCD01867530
NACRES	NA.32

半岛bd体育手机客户端 性质

质量水平	200
生物来源	mouse
重组	expressed in NSO cells
测定	>90% (SDS-PAGE)
形式	lyophilized powder
效能	0.16-10 ng/mL
分子量	monomer calculated mol wt 46.8 kDa 50-55 kDa by SDS-PAGE (reducing)
包装	pkg of 200 μg
储存条件	avoid repeated freeze/thaw cycles
杂质	endotoxin, tested
UniProt登记号	P20827
储存温度	?20℃
Gene Information	mouse ... Efna1(13636)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable