ODQ-CAS 41443-28-1-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A potent and selective inhibitor of nitric oxide (NO)-sensitive guanylyl cyclase (IC₅₀= 20 nM). In incubated cerebellum slices, ODQ reversibly inhibits the NO-dependent cGMP response to glutamate receptor agonists without affecting NOS activity. It does not chemically inactivate NO; however, it does inhibit cGMP generation in response to NO donors. ODQ fails to inhibit NO-mediated macrophage toxicity, a phenomenon unrelated to cGMP, nor does it affect the activity of particulate guanylyl cyclase or adenylyl cyclase.
A cell-permeable, potent and selective inhibitor of nitric oxide (NO)-sensitive guanylyl cyclase (IC₅₀= 20 nM). In incubated cerebellum slices, ODQ reversibly inhibits the NO-dependent cGMP response to glutamate receptor agonists without affecting NOS activity. It does not chemically inactivate NO; however, it does inhibit cGMP generation in response to NO donors. ODQ does not inhibit NO-mediated macrophage toxicity, a phenomenon unrelated to cGMP, nor does it affect the activity of particulate guanylyl cyclase or adenylyl cyclase.

包装

10 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Primary Target
(NO)-sensitive guanylyl cyclase
Product does not compete with ATP.
Target IC₅₀: 20 nM against nitric oxide (NO)-sensitive guanylyl cyclase
Reversible: yes

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Wang, D., et al. 1998.J. Biol. Chem.273,33027.
Southam, E., et al. 1996.Br. J. Pharmacol.119,527.
Brunner, F., et al. 1995.FEBS Lett.376,262.
Garthwaite, J., et al. 1995.Mol. Pharmacol.48,184.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C9H5N3O2
分子量	187.15
MDL编号	MFCD00792620

半岛bd体育手机客户端 性质

质量水平	100
测定	≥98% (TLC and HPLC)
形式	powder
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	light yellow
溶解性	DMSO: 25 mg/mL
运输	ambient
储存温度	?20℃
InChI	1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H
InChI key	LZMHWZHOZLVYDL-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable