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Anti-Arp1α/Centractin antibody produced in rabbit

品牌
Sigma-Aldrich
货号
A5601
规格纯度
IgG fraction of antiserum, buffered aqueous solution
价格
4731.57 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Anti-Arp1α/Centractin antibody produced in rabbit
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The actin-related protein Arp1α (centractin, actin-RPV), a member of the superfamily of actin-related proteins (Arp), is the major subunit of the dynactin complex, a key component of the cytoplasmic dynein motor machinery. It has been shown to localize to multiple structures within the cell, including membrane organelles, the centrosome, spindle poles, and spindle pole microtubules during mitosis and prometaphase kinetochores.

免疫原

synthetic peptide corresponding to the mid-region of human Arp1α/centractin (amino acids 222-240). This sequence is identical in mouse and dog Arp1α/centractin, highly conserved (89% identity) in the α-centractin isoform, and not found in known actin isoforms.

应用

Anti-Arp1α/Centractin antibody produced in rabbit has been used in immunoblotting and immunofluorescence staining.

生化/生理作用

The actin-related proteins (Arp)1α/dynactin complex regulates dyne mediated vesicle movement on microtubules as well as spindle assembly and cell division. Arp1α overexpression in cells results in aberrant spindle morphologies and cell cycle delay at prometaphase, suggesting a possible function of Arp1α/dynactin complex in progression through the prometaphase of mitosis. Expression of mutant Arp1a protein has no effect on mitotic cells, but results in microtubule disruption in interphase cells, by destabilizing the interaction between Arp1a and components of the dynactin complex and nuclear mitotic apparatus protein (NuMA).
Arp1α or Centractin is an actin-related, ubiquitious protein that forms a part of the dynactin complex and is associated with centrosomes. Studies have reported that centractin interacts with spectrin and subsequently provides a link for dynactin to associate with organelles in cells.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号 MFCD04040182
NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 IgG fraction of antiserum
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen 45 kDa
species reactivity human, rat, mouse
technique(s) indirect immunofluorescence: 1:100 using mouse fibroblasts NIH3T3 cell line
microarray: suitable
western blot: 1:1,000 using rat brain cytosol extract or whole cell extract of human epidermoid carcinoma A431 cell line.
UniProt登记号 P61163
运输 dry ice
储存温度 ?20℃
Gene Information human ... ACTR1A(10121)
mouse ... Actr1a(54130)
rat ... Actr1a(294010)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK nwg
闪点(F) Not applicable
闪点(C) Not applicable

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