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Anti-ABI1 antibody produced in rabbit

Anti-ABI1 兔抗

品牌
Sigma-Aldrich
货号
A5106
规格纯度
~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution
价格
4731.57 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Anti-ABI1 antibody produced in rabbit
Anti-Abl-interactor protein 1
Anti-Abelson interactor 1
Anti-spectrin SH3 domain binding protein 1 SSH3BP1
Anti-eps8 binding protein
Anti-interactor protein AblBP4
Anti-Nap1 binding protein NAP1BP
Anti-ABI1 兔抗
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Abi 1 is an adaptor protein that interacts with Wave2 to regulate actin polymerization.
Abelson interactor 1 (Abi1) protein, a 65 kD-substrate of the eponymous Abelson non-receptor tyrosine kinase (c-Abl) is expressed mainly in the central nervous system. This gene is located on human chromosome 10p12.

免疫原

synthetic peptide corresponding to amino acids 163-180 of human ABI1, conjugated to KLH. The corresponding sequence is identical in several species including mouse, rat, and dog.

应用

Anti-ABI1 antibody produced in rabbit has been used in western blot analysis and immunofluorescence.
Rabbit anti- ABI1 antibody can be used for immunoblotting assays at a concentration of 0.5-1.0μg/ml using extracts from A431 and rat brain cells.

生化/生理作用

Abelson interactor 1 (Abi1) is essential for the formation and activation of WAVE2 signaling complex. ABI1 and WAVE are essential for Rac-dependent membrane protrusion and macropinocytosis, whereas ABI1 and N-WASP regulate actin-based vesicular transport, EGF receptor endocytosis, and EGFR and transferrin receptor (TfR) cell surface distribution. ABI1 has been shown to act as dual regulator of WAVE and neural Wiskott-Aldrich syndrome protein (N-WASP) specific activities. ABI1 is an essential component of this signaling complex. It positively regulates WAVE activity and connects WAVE to Rac through assembly of the WAVE-ABI1-Nap1-PIR121 complex. Abi1 modulates actin reorganization and lamellipodia formation.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen ~65 kDa
species reactivity mouse (predicted), canine (predicted), human, rat
增强验证 recombinant expression
Learn more aboutAntibody Enhanced Validation
浓度 ~1.5 mg/mL
technique(s) western blot: 0.5-1.0 μg/mL using A431 cell lysate
western blot: 0.5-1.0 μg/mL using extract of rat brain cytosolic fraction (S1)
UniProt登记号 Q8IZP0
运输 dry ice
储存温度 ?20℃
Gene Information human ... ABI1(10006)
mouse ... Abi1(11308)
rat ... Abi1(79249)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable
个人防护装备 Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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